Document Detail


Degenerative jargon aphasia: Unusual progression of logopenic/phonological progressive aphasia?
MedLine Citation:
PMID:  22713376     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Primary progressive aphasia (PPA) corresponds to the gradual degeneration of language which can occur as nonfluent/agrammatic PPA, semantic variant PPA or logopenic variant PPA. We describe the clinical evolution of a patient with PPA presenting jargon aphasia as a late feature. At the onset of the disease (ten years ago) the patient showed anomia and executive deficits, followed later on by phonemic paraphasias and neologisms, deficits in verbal short-term memory, naming, verbal and semantic fluency. At recent follow-up the patient developed an unintelligible jargon with both semantic and neologistic errors, as well as with severe deficit of comprehension which precluded any further neuropsychological assessment. Compared to healthy controls, FDG-PET showed a hypometabolism in the left angular and middle temporal gyri, precuneus, caudate, posterior cingulate, middle frontal gyrus, and bilaterally in the superior temporal and inferior frontal gyri. The clinical and neuroimaging profile seems to support the hypothesis that the patient developed a late feature of logopenic variant PPA characterized by jargonaphasia and associated with superior temporal and parietal dysfunction.
Authors:
Paolo Caffarra; Simona Gardini; Stefano Cappa; Francesca Dieci; Letizia Concari; Caterina Ghetti; Livia Ruffini; Guido Dalla Rosa Prati
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-15
Journal Detail:
Title:  Behavioural neurology     Volume:  -     ISSN:  1875-8584     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-6-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8914585     Medline TA:  Behav Neurol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Neuroscience, University of Parma, Parma, Italy Outpatient Clinic for the Diagnosis and Therapy of Cognitive Disorders, AUSL, Parma, Italy.
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