Document Detail

Degeneration and regeneration of ganglion cell axons.
MedLine Citation:
PMID:  10649506     Owner:  NLM     Status:  MEDLINE    
The retino-tectal system has been used to study developmental aspects of axon growth, synapse formation and the establishment of a precise topographic order as well as degeneration and regeneration of adult retinal ganglion cell (RGC) axons after axonal lesion. This paper reviews some novel findings that provide new insights into the mechanisms of developmental RGC axon growth, pathfinding, and target formation. It also focuses on the cellular and molecular cascades that underlie RGC degeneration following an axonal lesion and on some therapeutic strategies to enhance survival of axotomized RGCs in vivo. In addition, this review deals with problems related to the induction of regeneration after axonal lesion in the adult CNS using the retino-tectal system as model. Different therapeutic approaches to promote RGC regeneration and requirements for specific target formation of regenerating RGCs in vitro and in vivo are discussed.
J Weise; R Ankerhold; M Bähr
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Microscopy research and technique     Volume:  48     ISSN:  1059-910X     ISO Abbreviation:  Microsc. Res. Tech.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-02-15     Completed Date:  2000-02-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9203012     Medline TA:  Microsc Res Tech     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  55-62     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Wiley-Liss, Inc.
Neurologische Universitätsklinik, 72076 Tübingen, Germany.
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MeSH Terms
Axons / pathology,  physiology*
Central Nervous System / cytology,  physiology
Embryonic and Fetal Development
Nerve Degeneration*
Nerve Growth Factors / physiology
Nerve Regeneration*
Organ Specificity
Retinal Ganglion Cells / physiology*
Signal Transduction
Reg. No./Substance:
0/Nerve Growth Factors

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