Document Detail


Degeneration and regeneration of ganglion cell axons.
MedLine Citation:
PMID:  10649506     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The retino-tectal system has been used to study developmental aspects of axon growth, synapse formation and the establishment of a precise topographic order as well as degeneration and regeneration of adult retinal ganglion cell (RGC) axons after axonal lesion. This paper reviews some novel findings that provide new insights into the mechanisms of developmental RGC axon growth, pathfinding, and target formation. It also focuses on the cellular and molecular cascades that underlie RGC degeneration following an axonal lesion and on some therapeutic strategies to enhance survival of axotomized RGCs in vivo. In addition, this review deals with problems related to the induction of regeneration after axonal lesion in the adult CNS using the retino-tectal system as model. Different therapeutic approaches to promote RGC regeneration and requirements for specific target formation of regenerating RGCs in vitro and in vivo are discussed.
Authors:
J Weise; R Ankerhold; M Bähr
Related Documents :
3558896 - Single-unit study of lateral line cells in the optic tectum of xenopus laevis: evidence...
10192526 - Cytochalasin d disrupts the restricted localization of n-cam, but not of l1, at sites o...
20192706 - Cocaine causes atrial purkinje fiber damage.
9454826 - Ethanol-gabaa receptor interactions: a comparison between cell lines and cerebellar pur...
3597136 - Influence of cis-dichlorodiamineplatinum on glioma cell morphology and cell cycle kinet...
16793256 - Development and evolution of the migratory neural crest: a gene regulatory perspective.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Microscopy research and technique     Volume:  48     ISSN:  1059-910X     ISO Abbreviation:  Microsc. Res. Tech.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-02-15     Completed Date:  2000-02-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9203012     Medline TA:  Microsc Res Tech     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  55-62     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Wiley-Liss, Inc.
Affiliation:
Neurologische Universitätsklinik, 72076 Tübingen, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Axons / pathology,  physiology*
Central Nervous System / cytology,  physiology
Embryonic and Fetal Development
Humans
Mammals
Nerve Degeneration*
Nerve Growth Factors / physiology
Nerve Regeneration*
Organ Specificity
Retinal Ganglion Cells / physiology*
Signal Transduction
Chemical
Reg. No./Substance:
0/Nerve Growth Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Novel Cystic Fibrosis mutation L1093P: functional analysis and possible Native American origin.
Next Document:  MAP1B expression and microtubule stability in growing and regenerating axons.