Document Detail

Degeneration of mammalian PNS and CNS axons is accelerated by incubation with protein synthesis inhibitors.
MedLine Citation:
PMID:  14630349     Owner:  NLM     Status:  MEDLINE    
Protein synthesis inhibitors (PSIs) increase the rate of degeneration, as measured by compound action potential (CAP) conduction, in segments of rat PNS and CNS axons. Sciatic axonal segments maintained in vitro in Krebs at 37-38 degrees C generate CAPs for 24 h compared to 8 h for axons exposed to Krebs containing two PSIs, 100 microM anisomycin and/or 35 microM cycloheximide. Spinal axonal segments at 37-38 degrees C generate CAPs for 3 h compared to 2 h for axons exposed to Krebs containing PSIs. While cooling (6-9 degrees C) slows degeneration rate, cooled sciatic axons exposed to PSIs exhibit lower peak CAPs compared to cooled control segments (P<0.005).
Ronda C Stavisky; Joshua M Britt; Aleksej Zuzek; Tuan Pham; Timothy C Marzullo; George D Bittner
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuroscience research     Volume:  47     ISSN:  0168-0102     ISO Abbreviation:  Neurosci. Res.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-11-21     Completed Date:  2004-01-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8500749     Medline TA:  Neurosci Res     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  445-9     Citation Subset:  IM    
Section of Neurobiology, The University of Texas at Austin, 1 University Station C0920, Austin, TX 78712-0248, USA.
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MeSH Terms
Action Potentials / drug effects
Anisomycin / pharmacology
Axons / drug effects*,  pathology
Cold Temperature
Cycloheximide / pharmacology
Dose-Response Relationship, Drug
Organ Culture Techniques
Protein Synthesis Inhibitors / pharmacology*
Rats, Sprague-Dawley
Sciatic Nerve / drug effects,  pathology
Spinal Cord / drug effects,  pathology
Wallerian Degeneration / metabolism*
Grant Support
Reg. No./Substance:
0/Protein Synthesis Inhibitors; 22862-76-6/Anisomycin; 66-81-9/Cycloheximide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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