Document Detail

Degeneration of cardiac sympathetic nerve can occur in multiple system atrophy.
MedLine Citation:
PMID:  17089131     Owner:  NLM     Status:  MEDLINE    
Decreased cardiac uptake of meta-iodobenzylguanidine (MIBG) on [(123)I] MIBG myocardial scintigraphy, a sensitive biological marker for Parkinson's disease (PD), is related to cardiac sympathetic denervation in patients with PD. A slight decrease in cardiac uptake of MIBG has also been reported in some patients with multiple system atrophy (MSA). However, the pathophysiological mechanism accounting for the slight decrease in MIBG uptake in MSA remains to be elucidated. For confirmation, we examined cardiac tissue and sympathetic ganglia from patients with MSA. We immunohistochemically examined each specimen of 15 patients with MSA together with 10 control subjects using antibodies against tyrosine hydroxylase (TH) and neurofilament (NF). The number of TH-immunoreactive nerve fibers in the epicardium was preserved in 8 of 15 patients with MSA as well as in 10 control subjects. The number of TH-immunoreactive, but not of NF-immunoreactive nerve fibers in the epicardium was mildly or moderately decreased in six patients with MSA, of whom four showed a decrease of TH immunoreactivity in the neuronal somata in the sympathetic ganglia. Moreover, TH- and NF-immunoreactive nerve fibers almost entirely disappeared in the heart of one patient with MSA, in whom Lewy body pathology was present in the sympathetic ganglia. These findings suggest that mild degeneration of the cardiac sympathetic nerve can occur in MSA which is closely related to the pathological change of neurons in the sympathetic ganglia, accounting for the slight decrease in cardiac uptake of MIBG. Moreover, concurrent Lewy body pathology in the sympathetic ganglia might accelerate cardiac sympathetic denervation even in MSA.
Satoshi Orimo; Toshiro Kanazawa; Ayako Nakamura; Toshiki Uchihara; Fumiaki Mori; Akiyoshi Kakita; Koichi Wakabayashi; Hitoshi Takahashi
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-11-07
Journal Detail:
Title:  Acta neuropathologica     Volume:  113     ISSN:  0001-6322     ISO Abbreviation:  Acta Neuropathol.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-11-22     Completed Date:  2007-10-26     Revised Date:  2007-11-09    
Medline Journal Info:
Nlm Unique ID:  0412041     Medline TA:  Acta Neuropathol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  81-6     Citation Subset:  IM    
Department of Neurology, Kanto Central Hospital, 6-25-1 Kami-Yoga, Setagaya-ku, Tokyo, 158-8531, Japan.
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MeSH Terms
Adrenergic Fibers / metabolism,  pathology*
Aged, 80 and over
Immunohistochemistry / methods
Inclusion Bodies / pathology
Middle Aged
Multiple System Atrophy / complications*,  pathology
Myocardium / pathology*
Neurodegenerative Diseases / etiology*,  metabolism
Neurofilament Proteins / metabolism
Tyrosine 3-Monooxygenase / metabolism
Reg. No./Substance:
0/Neurofilament Proteins; EC 3-Monooxygenase

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