Document Detail


Deforming arthropathy of the hands in systemic lupus erythematosus is associated with antibodies to SSA/Ro and to SSB/La.
MedLine Citation:
PMID:  7841997     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thirteen patients with systemic lupus erythematosus and deforming arthropathy (DA) of the hands were compared with 111 patients with SLE without deforming arthropathy. Clinical features were comparable in the two groups. Patients fulfilling criteria for mixed connective tissue disease (MCTD) were not included in the present study. A higher prevalence of antibodies to SSA/Ro (P < 0.0125) and SSB/La (P < 0.004) were found in the SLE-DA group. The detection of antibodies to SSA/Ro and SSB/La was even more strictly associated with DA in SLE antibodies to SSA/Ro alone (P < 0.002). Regarding the fine specificity of anti-SSA/Ro, a prevalent response to the 52 kD protein of the Ro antigen was found. We conclude that patients with SLE developing deformities of the hands belong to a subset of patients with circulating antibodies to SSA/Ro, particularly to the 52 kD component, and to SSB/La.
Authors:
F Franceschini; L Cretti; M Quinzanini; F L Rizzini; R Cattaneo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lupus     Volume:  3     ISSN:  0961-2033     ISO Abbreviation:  Lupus     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1995-03-06     Completed Date:  1995-03-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9204265     Medline TA:  Lupus     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  419-22     Citation Subset:  IM    
Affiliation:
Clinical Immunology Unit, Spedali Civili, University of Brescia, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Antibodies, Antinuclear / analysis,  immunology,  physiology*
Child
Female
Hand Deformities, Acquired / etiology*,  immunology,  pathology
Humans
Immunoblotting
Joint Diseases / etiology*,  immunology,  pathology
Lupus Erythematosus, Systemic / complications*,  immunology
Male
Middle Aged
Chemical
Reg. No./Substance:
0/Antibodies, Antinuclear; 0/SS-A antibodies; 0/SS-B antibodies

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