Document Detail


Deformationally dependent fluid transport properties of porcine coronary arteries based on location in the coronary vasculature.
MedLine Citation:
PMID:  23127633     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Understanding coronary artery mass transport allows researchers to better comprehend how drugs or proteins move through, and deposit into, the arterial wall. Characterizing how the convective component of transport changes based on arterial location could be useful to better understand how molecules distribute in different locations in the coronary vasculature.
METHODS AND RESULTS: We measured the mechanical properties and wall fluid flux transport properties of de-endothelialized (similar to post-stenting or angioplasty) left anterior descending (LADC) and right (RC) porcine coronary arteries along their arterial lengths. Multiphoton microscopy was used to determine microstructural differences. Proximal LADC regions had a higher circumferential stiffness than all other regions. Permeability decreased by 198% in the LADC distal region compared to other LADC regions. The RC artery showed a decrease of 46.9% from the proximal to middle region, and 51.7% from the middle to distal regions. The porosity increased in the intima between pressure states, without differences through the remainder of the arterial thickness.
CONCLUSIONS: We showed that the permeabilities and mechanical properties do vary in the coronary vasculature. With variations in mechanical properties, overexpansion of stents can occur more easily while variations in permeability may lead to altered transport based on location.
Authors:
Joseph T Keyes; Danielle R Lockwood; Bruce R Simon; Jonathan P Vande Geest
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-10-13
Journal Detail:
Title:  Journal of the mechanical behavior of biomedical materials     Volume:  17     ISSN:  1878-0180     ISO Abbreviation:  J Mech Behav Biomed Mater     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-03     Completed Date:  2013-05-21     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  101322406     Medline TA:  J Mech Behav Biomed Mater     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  296-306     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Coronary Vessels / cytology,  metabolism,  physiology*
Hydrodynamics*
Materials Testing*
Mechanical Processes*
Neovascularization, Physiologic*
Permeability
Swine
Grant Support
ID/Acronym/Agency:
1S10RR023737-01/RR/NCRR NIH HHS; T32 HL007955/HL/NHLBI NIH HHS; T32HL007955/HL/NHLBI NIH HHS
Comments/Corrections

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