Document Detail

Deformation and fragmentation of human red blood cells in turbulent shear flow.
MedLine Citation:
PMID:  1174639     Owner:  NLM     Status:  MEDLINE    
By means of glutaraldehyde fixation, human erythrocytes are "frozen" while suspended in turbulent shear flow. As the shearing is increased in steps from 100 to 2,500 dyn/cm2, the deformed cells evolve gradually toward a smooth ellipsoidal shape. At stresses above 2,500 dyn/cm2, approximately, fragmentation of the cells occurs with a concomitant increase in free hemoglobin content of the suspending medium. The photographic evidence suggests that the cells rupture in tension in the bulk flow.
S P Sutera; M H Mehrjardi
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biophysical journal     Volume:  15     ISSN:  0006-3495     ISO Abbreviation:  Biophys. J.     Publication Date:  1975 Jan 
Date Detail:
Created Date:  1975-12-30     Completed Date:  1975-12-30     Revised Date:  2010-09-09    
Medline Journal Info:
Nlm Unique ID:  0370626     Medline TA:  Biophys J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-10     Citation Subset:  IM    
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MeSH Terms
Erythrocytes* / cytology
Stress, Mechanical

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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