| Deformable liposomes by reverse-phase evaporation method for an enhanced skin delivery of (+)-catechin. | |
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MedLine Citation:
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PMID: 23356860 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Background: (+)-catechin, as the most common catechin isomer, is recognized to be an antioxidant which benefits the skin in many ways. The purpose of the present study was to prepare and evaluate a suitable liposomal delivery systems for (+)-catechin topical application. Methods: In this study, catechin-loaded conventional liposomal delivery system, deformable conventional liposomal delivery system and deformable liposomes prepared by reverse-phase evaporation (REV) method were compared. The three systems were characterized for liposome particle size, zeta-potential, entrapment efficiency, drug release, permeability across porcine skin and catechin deposition in the skin. Results: It was revealed that the size of deformable conventional liposomes before freeze-drying and deformable REV liposomes after freeze-drying range from 335.6 ± 71.7 nm to 551.1 ± 53.4 nm, respectively, which were considered to be suitable for skin delivery. The deformable REV liposomes had a higher aqueous volume and thus were able to entrap greater amounts of hydrophilic (+)-catechin (50.0 ± 5.9%) compared to conventional (30.0 ± 3.8%) and deformable conventional liposomes (36.1 ± 4.6%). All liposomal formulations exhibited a prolonged catechin release. Compared to deformable liposomes, the REV deformable liposomes showed a significantly better deposition of (+)-catechin while catechin solution did not permeate into the porcine ear skin. Conclusion: Among all formulations studied, deformable REV liposomes were considered to be favorable for catechin topical delivery. |
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Authors:
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Guanyu Chen; Danhui Li; Ye Jin; Weiyu Zhang; Lirong Teng; Craig Bunt; Jingyuan Wen |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-29 |
Journal Detail:
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Title: Drug development and industrial pharmacy Volume: - ISSN: 1520-5762 ISO Abbreviation: Drug Dev Ind Pharm Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7802620 Medline TA: Drug Dev Ind Pharm Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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School of Pharmacy, the University of Auckland , Auckland , New Zealand . |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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