| Definitive percutaneous treatment of lymphatic malformations of the trunk and extremities. | |
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MedLine Citation:
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PMID: 18206471 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The aim of this study is to investigate a new treatment regimen for macrocystic and microcystic lymphatic malformations (LMs) of the trunk and extremities. METHODS: Sixteen patients (aged 2 months-22 years) underwent percutaneous treatment for LM of the trunk and extremities from 2002 to 2007. The LM involved the arm, leg, axilla, chest, abdomen, scrotum, and penis. Eleven patients underwent primary treatment of LM; 5 were treated for recurrence after prior operative resection. Macrocysts (>or=1 cm) were treated with dual-drug chemoablation (sequential intracystic sodium tetradecyl sulfate and ethanol); doxycycline was used for microcysts. Macrocysts and microcysts were treated after complete cyst aspiration using sonographic guidance. Twenty-four macrocysts and 103 microcysts were treated. The goal of treatment was complete cyst ablation documented by sonography or magnetic resonance imaging. RESULTS: The mean number of treatments was 1.7 per patient; the mean number of treatments for macrocysts was 1.3 and for microcysts was 1.7. Ablation efficacy was 100% (127/127 cysts). Treatments included massive intraperitoneal cysts and cysts surrounding the adventitia of the brachial artery and brachial nerve. Infection occurred in 2 (13%) of 16 patients. No patient experienced postprocedural pain, skin necrosis, neuropathy, bowel obstruction, skin retraction, or myoglobinuria. CONCLUSIONS: Percutaneous sclerotherapy provides effective treatment for macrocystic and microcystic LM as primary treatment or for recurrence after surgical resection. |
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Authors:
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William E Shiels; Brian D Kenney; Donna A Caniano; Gail E Besner |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pediatric surgery Volume: 43 ISSN: 1531-5037 ISO Abbreviation: J. Pediatr. Surg. Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-01-21 Completed Date: 2008-02-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0052631 Medline TA: J Pediatr Surg Country: United States |
Other Details:
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Languages: eng Pagination: 136-9; discussion 140 Citation Subset: IM |
Affiliation:
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Department of Radiology, Nationwide Children's Hospital, The Ohio State University Medical Center, Columbus, OH 43205, USA. william.shiels@nationwidechildrens.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Cutaneous Adolescent Adult Child Child, Preschool Extremities Female Follow-Up Studies Humans Infant Lymphatic Abnormalities / pathology*, therapy*, ultrasonography Male Retrospective Studies Risk Assessment Sclerosing Solutions / therapeutic use* Sclerotherapy / methods* Severity of Illness Index Thorax Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Sclerosing Solutions |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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