Document Detail

Definitive diagnosis of neuroendocrine tumors using fine-needle aspiration-puncture guided by endoscopic ultrasonography.
MedLine Citation:
PMID:  21434714     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The detection and diagnosis of neuroendocrine tumors (NETs) is challenging. Endoscopic ultrasonography (EUS) has a significant role in the detection of NETs suspected from clinical manifestations or imaging techniques, as well as in their precise localization and cytological confirmation using EUS-Fine-needle aspiration-puncture (FNA).
OBJECTIVE: To assess the usefulness and precision of EUS-FNAP in the differential diagnosis and confirmation of NETs, in a retrospective review of our experience.
PATIENTS AND METHODS: in a total of 55 patients with suspected NETs who underwent radial or sectorial EUS, 42 tumors were detected in 40 cases. EUS-FNA using a 22G needle was performed for 16 cases with suspected functional (hormonal disorders: 6 cases) and non-functional NETs (10 cases). Ki 67 or immunocytochemistry (ICC) testing was performed for all.There was confirmation in 9 cases (5 female and 4 male) with a mean age of 51 years (range: 41-81 years).All tumors were located in the pancreas except for one in the mediastinum and one in the rectum, with a mean size of 19 mm (range: 10-40 mm).
RESULTS: There were no complications attributable to FNA. Sensitivity was 100% and both precision and PPV were 89%, as a false positive result suggested a diagnosis with NET during cytology that surgery finally revealed to be a pancreatic pseudopapillary solid tumor.
CONCLUSIONS: EUS-FNA with a 22G needle for NETs has high sensitivity and PPV at cytological confirmation with few complications.
J Gornals; M Varas; I Catalá; S Maisterra; C Pons; D Bargalló; T Serrano; J Fabregat
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva     Volume:  103     ISSN:  1130-0108     ISO Abbreviation:  Rev Esp Enferm Dig     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-25     Completed Date:  2011-07-25     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  9007566     Medline TA:  Rev Esp Enferm Dig     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  123-8     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Biopsy, Fine-Needle
Conscious Sedation
Ki-67 Antigen / analysis
Middle Aged
Neuroendocrine Tumors / diagnosis*,  pathology,  ultrasonography
Pancreatic Neoplasms / diagnosis
Predictive Value of Tests
Reproducibility of Results
Retrospective Studies
Tumor Markers, Biological / analysis
Reg. No./Substance:
0/Ki-67 Antigen; 0/Tumor Markers, Biological

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