Document Detail

Definitions and diagnosis of food intolerance and food allergy: consensus and controversy.
MedLine Citation:
PMID:  1447636     Owner:  NLM     Status:  MEDLINE    
This article describes the terms used for the various syndromes and diseases associated with reactions to foods; it outlines the principal types of food intolerance encountered in children, with particular emphasis on those caused by immune-mediated reactions of immediate hypersensitivity. Terms defined include food intolerance or food sensitivity; food allergy or food hypersensitivity; psychologically based food reactions (food aversions); and psychosocial and neurologic dysfunction. The spectrum of food sensitivity is considerable, and diagnosis is generally based on the monitoring of effects of exclusion diets and provocation tests, after appropriate objective measures are first selected. In children, manifestations of IgE-mediated food allergy (often in association with other immune mechanisms) include self-limiting and immediate reactions (e.g., urticaria, wheeze) and chronic diseases (food-sensitive enteropathies, eczema). Controversial and unresolved issues exist with some other conditions, including eosinophilic gastroenteritis, occult gastrointestinal bleeding, protein-losing enteropathy, and attention deficit disorder with hyperactivity. New methods for clinical investigation of gastrointestinal tract function and intestinal immune reactions are required to assess the relevance of foods in these conditions.
A Ferguson
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  121     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1992-12-24     Completed Date:  1992-12-24     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S7-11     Citation Subset:  AIM; IM    
Department of Medicine (Western General Hospital), University of Edinburgh, Scotland.
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MeSH Terms
Antigen-Antibody Reactions
Food Hypersensitivity* / complications,  diagnosis,  diet therapy,  immunology,  psychology
Gastrointestinal Diseases / etiology
Hypersensitivity, Immediate* / complications,  diagnosis,  diet therapy,  immunology
Immune Tolerance
Immunoglobulin E / immunology
Milk Hypersensitivity / complications,  immunology
Reg. No./Substance:
37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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