Document Detail


Definition of a conserved immunodominant domain on hepatitis C virus E2 glycoprotein by neutralizing human monoclonal antibodies.
MedLine Citation:
PMID:  18400849     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Development of a successful hepatitis C virus (HCV) vaccine requires the definition of neutralization epitopes that are conserved among different HCV genotypes. Five human monoclonal antibodies (HMAbs) are described that cross-compete with other antibodies to a cluster of overlapping epitopes, previously designated domain B. Each HMAb broadly neutralizes retroviral pseudotype particles expressing HCV E1 and E2 glycoproteins, as well as the infectious chimeric genotype 1a and genotype 2a viruses. Alanine substitutions of residues within a region of E2 involved in binding to CD81 showed that critical E2 contact residues involved in the binding of representative antibodies are identical to those involved in the binding of E2 to CD81.
Authors:
Zhen-Yong Keck; Ta-Kai Li; Jinming Xia; Meital Gal-Tanamy; Oakley Olson; Sophia H Li; Arvind H Patel; Jonathan K Ball; Stanley M Lemon; Steven K H Foung
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-04-09
Journal Detail:
Title:  Journal of virology     Volume:  82     ISSN:  1098-5514     ISO Abbreviation:  J. Virol.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-23     Completed Date:  2008-08-12     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6061-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Alanine / metabolism
Amino Acid Substitution
Antibodies, Monoclonal / immunology*,  metabolism
Hepacivirus / immunology*
Hepatitis C Antibodies / immunology*
Humans
Immunodominant Epitopes / immunology*
Neutralization Tests
Viral Envelope Proteins / chemistry,  genetics,  immunology*,  metabolism
Grant Support
ID/Acronym/Agency:
HL079381/HL/NHLBI NIH HHS; MC_U130184144//Medical Research Council; U19-AI40035/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Hepatitis C Antibodies; 0/Immunodominant Epitopes; 0/Viral Envelope Proteins; 157184-61-7/glycoprotein E2, Hepatitis C virus; OF5P57N2ZX/Alanine
Comments/Corrections

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