| Definition of the clinical spectrum of kernicterus and bilirubin-induced neurologic dysfunction (BIND). | |
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MedLine Citation:
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PMID: 15578034 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Kernicterus, currently used to describe both the neuropathology of bilirubin-induced brain injury and its associated clinical findings, is a complex syndrome. The neurobiology of kernicterus, including the determinants and mechanisms of neuronal injury, is discussed along with traditional and evolving definitions ranging from classical kernicterus with athetoid cerebral palsy, impaired upward gaze and deafness, to isolated conditions, for example, auditory neuropathy or dys-synchrony (AN/AD), and subtle bilirubin-induced neurological dysfunction (BIND). The clinical expression of BIND varies with location, severity, and time of assessment, influenced by the amount, duration and developmental age of exposure to excessive free bilirubin. Although total serum bilirubin (TSB) is important, kernicterus cannot be defined based solely on TSB. For study purposes kernicterus may be defined in term and near-term infants with TSB > or = 20 mg/dl using abnormal muscle tone on examination, auditory testing diagnostic of AN/AD, and magnetic resonance imaging showing bilateral lesions of globus pallidus+/-subthalamic nucleus. |
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Authors:
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Steven M Shapiro |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of perinatology : official journal of the California Perinatal Association Volume: 25 ISSN: 0743-8346 ISO Abbreviation: J Perinatol Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2004-12-20 Completed Date: 2005-05-05 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8501884 Medline TA: J Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 54-9 Citation Subset: IM |
Affiliation:
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Division of Child Neurology, Departments of Neurology and Pediatrics, Medical College of Virginia Campus, Virginia Commonwealth University Medical Center, Richmond, VA 33298, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Basal Ganglia / pathology, physiopathology Evoked Potentials, Auditory, Brain Stem / physiology Humans Infant Infant, Newborn Kernicterus / diagnosis*, etiology*, physiopathology Severity of Illness Index |
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