| Definition of the CTV Prostate in CT and MRI by Using CT-MRI Image Fusion in IMRT Planning for Prostate Cancer. | |
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MedLine Citation:
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PMID: 21347638 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: : To determine the prostate volumes defined by using MRI and CT scans, as well as the difference between prostate delineation in MRI and CT in three dimensions (3D). A further goal was to use MRI to identify subgroups of patients in whom seminal vesicle irradiation can be avoided. METHODS AND MATERIALS: : A total of 294 patients with biopsy-proven prostate cancer (MRI stages: T(1), 16 [5%]; T(2), 84 [29%]; T(3), 191 [65%]; T(4), 3 [1%]) underwent pelvic CT and MRI scans before intensity-modulated radiation therapy (IMRT) planning. 3D images were used to compare the prostate volumes defined by superimposed MR and CT images. Prostate volumes were calculated in cm(3). RESULTS: : The mean prostate volume defined by MRI (44.3 cm(3) [range, 8.8-182.8 cm(3)]) was 35% smaller than that defined by CT (68.5 cm(3) [range, 15.2-241.3 cm(3)]). The areas of nonagreement were observed predominantly in the most superior and inferior portions of the prostate. The incidence of seminal vesicle invasion (SVI) identified by MRI was 63% (n = 182 of 290). The median length of SVI was 2.6 cm (range, 1.1-4.7 cm; 62% of the median SV length). The low-risk patients (59%, n = 171 of 290) calculated by applying the Roach and Diaz formula had a SVI rate of 57% (n = 97 of 171), the high-risk patients (41%, n = 119 of 290) of 71% (n = 85 of 119). CONCLUSIONS: : Compared with MRI, CT scans overestimate prostate volume by 35%. CT-MRI image fusion-based treatment planning allows more accurate prediction of the correct staging and more precise target volume identification in prostate cancer patients. |
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Authors:
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Bettina Hentschel; Wolfgang Oehler; Dirk Strauß; Andreas Ulrich; Ansgar Malich |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-24 |
Journal Detail:
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Title: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] Volume: - ISSN: 1439-099X ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8603469 Medline TA: Strahlenther Onkol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Radiation Oncology and Radiotherapy, Südharz-Krankenhaus, Nordhausen, Germany, bettina.hentschel@shk-ndh.de. |
Vernacular Title:
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Definition des CTV Prostata in CT und MRT anhand CT-MRI-Bildfusion für die IMRT-Planung des Prostatakarzinoms. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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