| Defining the role of Emi1 in the DNA replication-segregation cycle. | |
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MedLine Citation:
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PMID: 18317792 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ordered progression through the cell cycle is essential to maintain genomic stability, and fundamental to this is ubiquitin-mediated proteolysis. In particular, the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase destabilises specific regulators at defined times in the cycle to ensure that each round of DNA replication is followed by cell division. Thus, the proper regulation of the APC/C is crucial in each cell cycle. There are several APC/C regulators that restrict its activity to specific cell cycle phases, and amongst these the early mitotic inhibitor 1 (Emi1) protein has recently come to prominence. Emi1 has been proposed to control APC/C in early mitosis; however, recent evidence questions this role. In this review we discuss new evidence that indicates that Emi1 is essential to restrict APC/C activity in interphase and, by doing so, ensure the proper coordination between DNA replication and mitosis. |
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Authors:
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Barbara Di Fiore; Jonathon Pines |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2008-03-04 |
Journal Detail:
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Title: Chromosoma Volume: 117 ISSN: 0009-5915 ISO Abbreviation: Chromosoma Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-03 Completed Date: 2008-10-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985138R Medline TA: Chromosoma Country: Germany |
Other Details:
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Languages: eng Pagination: 333-8 Citation Subset: IM |
Affiliation:
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Wellcome Trust/Cancer Research UK Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, Cambridge, UK. b.difiore@gurdon.cam.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Cycle Proteins
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metabolism* Chromosome Segregation / physiology* DNA Replication / physiology* F-Box Proteins / metabolism* Mitosis / physiology* Signal Transduction / physiology Ubiquitin-Protein Ligase Complexes / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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//Cancer Research UK |
| Chemical | |
Reg. No./Substance:
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0/Cell Cycle Proteins; 0/F-Box Proteins; 0/FBXO5 protein, human; EC 6.3.2.19/Ubiquitin-Protein Ligase Complexes; EC 6.3.2.19/anaphase-promoting complex |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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