| Defining normal and abnormal fetal growth: promises and challenges. | |
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MedLine Citation:
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PMID: 20074690 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Normal fetal growth is a critical component of a healthy pregnancy and influences the long-term health of the offspring. However, defining normal and abnormal fetal growth has been a long-standing challenge in clinical practice and research. We review various references and standards that are used widely to evaluate fetal growth and discuss common pitfalls of current definitions of abnormal fetal growth. Pros and cons of different approaches to customize fetal growth standards are described. We further discuss recent advances toward an integrated definition for fetal growth restriction. Such a definition may incorporate fetal size with the status of placental health that is measured by maternal and fetal Doppler velocimetry and biomarkers, biophysical findings, and genetics. Although the concept of an integrated definition appears promising, further development and testing are required. An improved definition of abnormal fetal growth should benefit both research and clinical practice. |
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Authors:
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Jun Zhang; Mario Merialdi; Lawrence D Platt; Michael S Kramer |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural; Review Date: 2010-01-13 |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 202 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-31 Completed Date: 2010-06-22 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 522-8 Citation Subset: AIM; IM |
Copyright Information:
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Published by Mosby, Inc. |
Affiliation:
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Epidemiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Female Fetal Development / physiology* Fetal Growth Retardation / diagnosis* Gestational Age Humans Infant, Newborn Infant, Small for Gestational Age / growth & development* Pregnancy Reference Values |
| Grant Support | |
ID/Acronym/Agency:
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NIH0010199548//PHS HHS |
| Comments/Corrections | |
Comment In:
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Am J Obstet Gynecol. 2010 Jun;202(6):513
[PMID:
20510957
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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