| Defining the mechanical border zone: a study in the pig heart. | |
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MedLine Citation:
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PMID: 4014488 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Wall motion abnormalities can occur in nonischemic areas contiguous with ischemic myocardium. The extent of the mechanical border zone contiguous with an acute myocardial ischemic region was mapped in eight open-chest anesthetized pigs using sonomicrometer crystals implanted parallel with the visible ischemic border in the subepicardium of ischemic (IZ), proximal border (BZ1), distal border (BZ2), and remote normal (NZ) zones. Regional systolic shortening fraction was near 15%, and epicardial blood flow was approximately 1.5 ml X min-1 X g-1 in all locations before ischemia was induced. Blood flow fell to less than 0.05 ml X min-1 X g-1 and the left ventricular free wall supplied by the distal one-third of the left anterior descending artery exhibited holosystolic lengthening when the vessel was occluded. After occlusion, systolic shortening fraction was depressed by 45% in the BZ1 located 3.1 +/- 1.1 mm from the ischemic margin and by 25% in the BZ2, which was measured at 9.3 +/- 1.5 mm from the ischemic margin without significant flow reduction. The NZ, 22.3 +/- 4.6 mm from ischemic margin, was unaffected by occlusion. Computer analysis of the data shows that wall motion is depressed as far as 12 mm from the ischemic margin. This abnormal wall motion surrounding focal transmural myocardial ischemia is presumed to result from mechanical tethering. |
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Authors:
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K Sakai; K Watanabe; R W Millard |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of physiology Volume: 249 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1985 Jul |
Date Detail:
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Created Date: 1985-08-13 Completed Date: 1985-08-13 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H88-94 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Flow Velocity Blood Pressure Coronary Circulation Coronary Disease / physiopathology* Female Heart Rate Male Microspheres Myocardial Contraction* Radioisotopes / diagnostic use Swine / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Radioisotopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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