Document Detail


Defining key features of the broad autism phenotype: a comparison across parents of multiple- and single-incidence autism families.
MedLine Citation:
PMID:  17948871     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study examined the frequency of personality, language, and social-behavioral characteristics believed to comprise the broad autism phenotype (BAP), across families differing in genetic liability to autism. We hypothesized that within this unique sample comprised of multiple-incidence autism families (MIAF), single-incidence autism families (SIAF), and control Down syndrome families (DWNS), a graded expression would be observed for the principal characteristics conferring genetic susceptibility to autism, in which such features would express most profoundly among parents from MIAFs, less strongly among SIAFs, and least of all among comparison parents from DWNS families, who should display population base rates. Analyses detected linear expression of traits in line with hypotheses, and further suggested differential intrafamilial expression across family types. In the vast majority of MIAFs both parents displayed BAP characteristics, whereas within SIAFs, it was equally likely that one, both, or neither parent show BAP features. The significance of these findings is discussed in relation to etiologic mechanisms in autism and relevance to molecular genetic studies.
Authors:
Molly Losh; Debra Childress; Kristen Lam; Joseph Piven
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics     Volume:  147B     ISSN:  1552-485X     ISO Abbreviation:  Am. J. Med. Genet. B Neuropsychiatr. Genet.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-26     Completed Date:  2008-07-23     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  101235742     Medline TA:  Am J Med Genet B Neuropsychiatr Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  424-33     Citation Subset:  IM    
Copyright Information:
(c) 2007 Wiley-Liss, Inc.
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MeSH Terms
Descriptor/Qualifier:
Adult
Autistic Disorder / etiology*
Down Syndrome
Genetic Predisposition to Disease
Humans
Incidence
Inheritance Patterns
Nuclear Family
Parents*
Phenotype
Grant Support
ID/Acronym/Agency:
K12 HD052191/HD/NICHD NIH HHS; L30 MH081741/MH/NIMH NIH HHS; L30 MH081741-01/MH/NIMH NIH HHS; R03 MH079998/MH/NIMH NIH HHS; R03 MH079998-01A1/MH/NIMH NIH HHS; U54 MH66418/MH/NIMH NIH HHS
Comments/Corrections

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