| Defining criteria for anti-mannan antibodies to protect against candidiasis. | |
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MedLine Citation:
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PMID: 15977994 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prevention of hematogenously disseminated candidiasis and mucocutaneous disease, including Candida vaginitis, through immunological approaches is appealing for the following reason. A long-acting and safe vaccine that protects against both serotypes of Candida albicans and other important species, such as C. tropicalis and C. glabrata, should significantly reduce the incidence of various forms of candidiasis by these etiologic agents. Through extensive experimentation on protective responses in experimental animals against Candida mannan components, others and we have evidence that antibodies specific for short-chain beta-linked oligomannosides are protective against candidiasis. Although the mechanism of protection against vaginal infection requires further investigation, experimentally the ability of antibody to rapidly deposit high amounts of complement factor C3 onto the yeast cell wall is requisite for enhancing resistance against disseminated candidiasis. |
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Authors:
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J E Cutler |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Current molecular medicine Volume: 5 ISSN: 1566-5240 ISO Abbreviation: Curr. Mol. Med. Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-06-27 Completed Date: 2005-08-25 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 101093076 Medline TA: Curr Mol Med Country: Netherlands |
Other Details:
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Languages: eng Pagination: 383-92 Citation Subset: IM |
Affiliation:
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The Research Institute for Children and LSUHSC, Dept of Pediatrics and Dept of Microbiology, Children's Hospital, New Orleans, LA 70118, USA. jcutler@chnola-research.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Fungal / blood, immunology* Antibodies, Monoclonal / therapeutic use* Candida albicans / immunology, metabolism Candidiasis / blood, immunology*, prevention & control* Cell Wall / metabolism Complement C3 / metabolism Female Humans Mannans / immunology, therapeutic use* |
| Grant Support | |
ID/Acronym/Agency:
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P01 AI061537/AI/NIAID NIH HHS; P01 AI37194/AI/NIAID NIH HHS; R01 AI24912/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Fungal; 0/Antibodies, Monoclonal; 0/Complement C3; 0/Mannans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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