Document Detail

Defining treatment response in pediatric tic disorders: a signal detection analysis of the Yale Global Tic Severity Scale.
MedLine Citation:
PMID:  22070181     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the optimal Yale Global Tic Severity Scale (YGTSS) percent reduction and raw cutoffs for predicting treatment response among children and adolescents with tic disorders.
METHOD: Youth with a tic disorder (N=108; range=5-17 years) participated in several clinical trials involving varied medications or psychosocial treatment, or received naturalistic care. Assessments were conducted before and after treatment and included the YGTSS and response status on the Clinical Global Impressions-Improvement Scale (CGI-I).
RESULTS: A 35% reduction on the YGTSS total tic severity score or a YGTSS raw total tic severity score change of 6 or 7 points were the best indicators of clinical treatment response in youth with tic disorders.
CONCLUSIONS: A YGTSS total tic severity score reduction of 35% or a raw total tic severity score change of 6 or 7 appears optimal for determining treatment response. A consistent definition of treatment response on the YGTSS may facilitate cross-study comparability. Practitioners can use these values for treatment planning decisions (e.g., change medications, etc.).
Eric A Storch; Alessandro S De Nadai; Adam B Lewin; Joseph F McGuire; Anna M Jones; P Jane Mutch; R Doug Shytle; Tanya K Murphy
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-11-09
Journal Detail:
Title:  Journal of child and adolescent psychopharmacology     Volume:  21     ISSN:  1557-8992     ISO Abbreviation:  J Child Adolesc Psychopharmacol     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-26     Completed Date:  2012-04-24     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  9105358     Medline TA:  J Child Adolesc Psychopharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  621-7     Citation Subset:  IM    
Department of Pediatrics, University of South Florida, Tampa, FL, USA.
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MeSH Terms
Child, Preschool
Clinical Trials as Topic / psychology,  statistics & numerical data
Outcome Assessment (Health Care) / methods,  statistics & numerical data*
Predictive Value of Tests
Severity of Illness Index*
Signal Detection, Psychological*
Tic Disorders / diagnosis*

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