| Defining patients at high risk for gastrointestinal hemorrhage after drug-eluting stent placement: a cost utility analysis. | |
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MedLine Citation:
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PMID: 20236217 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: The study goal was to evaluate the cost-effectiveness of drug-eluting stent (DES) placement with consideration of gastrointestinal (GI) bleeding risk. DES reduce the need for future coronary revascularization, but require prolonged dual anti-platelet (DAT) therapy, which may increase the risk for GI bleeding. While DES have been found to be cost-effective in patients at average risk for GI bleeding, they may not be the most cost-effective strategy in higher risk patients. METHODS: A Markov model was created to compare DES with bare metal stents (BMS). Patients were a hypothetical cohort of 60-year-old individuals with coronary artery stenosis that required nonemergent percutaneous coronary revascularization (PCI). The primary outcomes were the threshold incremental risks of GI bleeding from DAT based on willingness to pay (WTP) of $50,000, $100,000, and $150,000 per quality adjusted life year (QALY) gained. RESULTS: For a WTP of $100,000, the relative risk of GI bleeding from DAT could be as high as 10.8 (when compared to aspirin alone) before DES would no longer be cost-effective. In patients with two risk factors for GI bleeding, the threshold relative risk could be as low as 1.6. CONCLUSION: In average-risk patients, the risk of GI bleeding from DAT can be substantial without affecting the cost-effectiveness of DES. However, DES are unlikely to be cost-effective in patients with two or more risk factors for GI bleeding. |
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Authors:
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Neil Gupta; Rahul Nayak; Scott W Grisolano; Daniel C Buckles; Peter N Tadros |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2010-03-02 |
Journal Detail:
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Title: Journal of interventional cardiology Volume: 23 ISSN: 1540-8183 ISO Abbreviation: J Interv Cardiol Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-05-14 Completed Date: 2010-08-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8907826 Medline TA: J Interv Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 179-87 Citation Subset: IM |
Affiliation:
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Division of Gastroenterology/Hepatology, University of Kansas Medical Center, Kansas City, KS 66160, USA. ngupta@kumc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Transluminal, Percutaneous Coronary Aspirin / therapeutic use Cohort Studies Coronary Stenosis / therapy* Cost-Benefit Analysis Drug-Eluting Stents / adverse effects*, economics* Equipment Design Gastrointestinal Hemorrhage / etiology* Humans Markov Chains Middle Aged Patients* Quality-Adjusted Life Years Risk Risk Assessment Stents / adverse effects |
| Chemical | |
Reg. No./Substance:
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50-78-2/Aspirin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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