| Defining a PARticular pathway of neural tube closure. | |
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MedLine Citation:
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PMID: 20152170 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mammalian neurulation is completed when the dorsolateral neural folds bend inwards, their tips make adhesive contacts across the midline, and the epithelia remodel to create a closed neural tube. Two recent papers (one by Camerer et al. in this issue of Developmental Cell) demonstrate a vital role for protease-activated G protein-coupled receptor signaling in these late closure events, opening up new avenues for exploring the molecular basis of mammalian neural tube morphogenesis. |
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Authors:
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Andrew J Copp; Nicholas D E Greene |
Publication Detail:
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Type: Comment; Journal Article |
Journal Detail:
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Title: Developmental cell Volume: 18 ISSN: 1878-1551 ISO Abbreviation: Dev. Cell Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-15 Completed Date: 2010-03-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101120028 Medline TA: Dev Cell Country: United States |
Other Details:
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Languages: eng Pagination: 1-2 Citation Subset: IM |
Copyright Information:
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(c) 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK. a.copp@ich.ucl.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Central Nervous System / cytology, embryology*, metabolism* Epithelial Cells / cytology, metabolism Humans Mice Neural Tube / cytology, embryology*, metabolism* Neural Tube Defects / genetics, metabolism, physiopathology Neurons / cytology, metabolism Receptor, PAR-1 / genetics, metabolism Receptor, PAR-2 / genetics, metabolism Receptors, G-Protein-Coupled / genetics, metabolism* Receptors, Proteinase-Activated / genetics, metabolism* Signal Transduction / physiology Stem Cells / cytology, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Receptor, PAR-1; 0/Receptor, PAR-2; 0/Receptors, G-Protein-Coupled; 0/Receptors, Proteinase-Activated |
| Comments/Corrections | |
Comment On:
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Dev Cell. 2010 Jan 19;18(1):25-38
[PMID:
20152175
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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