| Defining the Minimal Detectable Change in Scores on the Eight-Item Morisky Medication Adherence Scale (May). | |
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MedLine Citation:
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PMID: 21521862 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Self-report scales are used to assess medication adherence. Data on how to discriminate change in self-reported adherence over time from random variability are limited. OBJECTIVE: To determine the minimal detectable change for scores on the 8-item Morisky Medication Adherence Scale (MMAS-8). METHODS: The MMAS-8 was administered twice, using a standard telephone script, with administration separated by 14-22 days, to 210 participants taking antihypertensive medication in the CoSMO (Cohort Study of Medication Adherence among Older Adults). MMAS-8 scores were calculated and participants were grouped into previously defined categories (<6, 6 to <8, and 8 for low, medium, and high adherence). RESULTS: The mean (SD) age of participants was 78.1 (5.8) years, 43.8% were 51.0% (107/210) of participants had low, medium, and high MMAS-8 scores, respectively, at both survey administrations (overall agreement 75.2%; 158/210). The weighted k statistic was 0.63 (95% CI 0.53 to 0.72). The intraclass correlation coefficient was 0.78. The within-person standard error of the mean for change in MMAS-8 scores was 0.81, which equated to a minimal detectable change of 1.98 points. Only 4.3% (9/210) of the participants had a change in MMAS-8 of 2 or more points between survey administrations. CONCLUSIONS: Within-person changes in MMAS-8 scores of 2 or more points over time may represent a real change in antihypertensive medication adherence. |
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Authors:
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Paul Muntner; Cara Joyce; Elizabeth Holt; Jiang C He; Donald Morisky; Larry S Webber; Marie Krousel-Wood |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-26 |
Journal Detail:
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Title: The Annals of pharmacotherapy Volume: - ISSN: 1542-6270 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9203131 Medline TA: Ann Pharmacother Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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