Document Detail


Defining cerebrospinal fluid white blood cell count reference values in neonates and young infants.
MedLine Citation:
PMID:  20064869     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Cerebrospinal fluid (CSF) white blood cell (WBC) counts for neonates and young infants are usually interpreted on the basis of values reported in reference texts or handbooks; however, current reference texts either present normal CSF parameters without citation or cite studies with significant limitations. The objective of this study was to determine accurate, age-specific reference values for CSF WBC counts in a large population of neonates and young infants.
METHODS: This cross-sectional study included patients who were aged < or =56 days and had a lumbar puncture performed in the emergency department from January 1, 2005, to June 30, 2007. Patients were excluded from analysis for conditions that are suspected to cause CSF pleocytosis, including traumatic lumbar puncture, serious bacterial infection, congenital infection, seizure, and presence of a ventricular shunt. Children who tested positive for enterovirus (EV) in the CSF by polymerase chain reaction were also excluded. Two-sample Wilcoxon rank-sum tests were used to compare median CSF WBC values of those who had negative EV testing with those who did not have EV testing.
RESULTS: A total of 380 (36%) of 1064 patients met inclusion criteria; 54% were male, 15% were preterm, and 39% presented during EV season. The median CSF WBC count was significantly higher in infants who were aged < or =28 days (3/microL, 95th percentile: 19/microL) than in infants who were aged 29 to 56 days (2/microL, 95th percentile: 9/microL; P < .001). In both age groups, infants with a negative EV PCR had a higher upper bound of the 95% confidence interval of the mean values compared with infants who did not have EV testing performed.
CONCLUSIONS: We determined age-specific CSF WBC reference values in a large cohort of neonates and young infants that can be used to interpret accurately the results of lumbar punctures in this population.
Authors:
Lori A Kestenbaum; Jessica Ebberson; Joseph J Zorc; Richard L Hodinka; Samir S Shah
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-01-11
Journal Detail:
Title:  Pediatrics     Volume:  125     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-03     Completed Date:  2010-03-04     Revised Date:  2012-01-31    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  257-64     Citation Subset:  AIM; IM    
Affiliation:
MSCE, Children's Hospital of Philadelphia, Division of Infectious Diseases, Room 1526 (North Campus), 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA.
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MeSH Terms
Descriptor/Qualifier:
Cerebrospinal Fluid / cytology*
Cross-Sectional Studies
Female
Humans
Infant
Infant, Newborn
Infant, Premature
Leukocyte Count*
Male
Reference Values
Sepsis / cerebrospinal fluid
Spinal Puncture
Grant Support
ID/Acronym/Agency:
K01 AI073729-03/AI/NIAID NIH HHS; K01 AI073729-04/AI/NIAID NIH HHS; K01 AI073729-06/AI/NIAID NIH HHS; K01 AI73729/AI/NIAID NIH HHS
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