Document Detail

Defining an Acidosis-Based Ischemic Penumbra from pH-Weighted MRI.
MedLine Citation:
PMID:  22408691     Owner:  NLM     Status:  PubMed-not-MEDLINE    
It has been proposed that the spatial mismatch between deficits on perfusion-weighted imaging (PWI) and diffusion-weighted imaging (DWI) in MRI can be used to decide regarding thrombolytic treatment in acute stroke. However, uncertainty remains about the meaning and reversibility of the perfusion deficit and even part of the diffusion deficit. Thus, there remains a need for continued development of imaging technology that can better define a potentially salvageable ischemic area at risk of infarction. Amide proton transfer (APT) imaging is a novel MRI method that can map tissue pH changes, thus providing the potential to separate the PWI/DWI mismatch into an acidosis-based penumbra and a zone of benign oligemia. In this totally noninvasive method, the pH dependence of the chemical exchange between amide protons in endogenous proteins and peptides and water protons is exploited. Early results in animal models of ischemia show promise to derive an acidosis penumbra. Possible translation to the clinic and hurdles standing in the way of achieving this are discussed.
Jinyuan Zhou; Peter C M van Zijl
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Translational stroke research     Volume:  3     ISSN:  1868-4483     ISO Abbreviation:  Transl Stroke Res     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2013-12-10     Completed Date:  2013-12-11     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  101517297     Medline TA:  Transl Stroke Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  76-83     Citation Subset:  -    
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Grant Support
P41 EB015909/EB/NIBIB NIH HHS; P41 EB015909-12/EB/NIBIB NIH HHS; P41 RR015241/RR/NCRR NIH HHS; P41 RR015241-11/RR/NCRR NIH HHS; R01 EB009731/EB/NIBIB NIH HHS; R01 EB009731-01/EB/NIBIB NIH HHS; R01 EB009731-02/EB/NIBIB NIH HHS; R01 EB009731-03/EB/NIBIB NIH HHS; R01 EB009731-04/EB/NIBIB NIH HHS; R01 EB015032/EB/NIBIB NIH HHS; R01 EB015032-01/EB/NIBIB NIH HHS; R01 EB015032-02/EB/NIBIB NIH HHS; R21 EB009112/EB/NIBIB NIH HHS; R21 EB009112-01A1/EB/NIBIB NIH HHS; R21 EB009112-02/EB/NIBIB NIH HHS

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