Document Detail


Deficits in landmark navigation and path integration after lesions of the interpeduncular nucleus.
MedLine Citation:
PMID:  19485555     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Experiments were designed to determine the role of the interpeduncular nucleus (IPN) in 3 forms of navigation: beacon, landmark, and path integration. In beacon navigation, animals reach goals using cues directly associated with them, whereas in landmark navigation animals use external cues to determine a direction and distance to goals. Path integration refers to the use of self-movement cues to obtain a trajectory to a goal. IPN-lesioned rats were tested in a food-carrying task in which they searched for food in an open field, and returned to a refuge after finding the food. Landmark navigation was evaluated during trials performed under lighted conditions and path integration was tested under darkened conditions, thus eliminating external cues. We report that IPN lesions increased the number of errors and reduced heading accuracy under both lighted and darkened conditions. Tests using a Morris water maze procedure indicated that IPN lesions produced moderate impairments in the landmark version of the water task, but left beacon navigation intact. These findings suggest that the IPN plays a fundamental role in landmark navigation and path integration.
Authors:
Benjamin J Clark; Jeffrey S Taube
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  123     ISSN:  0735-7044     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-02     Completed Date:  2009-08-13     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  490-503     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009 APA, all rights reserved.
Affiliation:
Department of Psychological and Brain Sciences, Center for Cognitive Neuroscience, Dartmouth College, Hanover, NH 03755, USA.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Cues
Darkness
Female
Food
Maze Learning / physiology
Mesencephalon / physiology*
Rats
Rats, Long-Evans
Space Perception / physiology*
Spatial Behavior / physiology*
Swimming
Task Performance and Analysis
Vision, Ocular
Grant Support
ID/Acronym/Agency:
NS053907/NS/NINDS NIH HHS; R01 DC009318-04/DC/NIDCD NIH HHS; R01 NS053907/NS/NINDS NIH HHS; R01 NS053907-11/NS/NINDS NIH HHS; R01 NS053907-12/NS/NINDS NIH HHS; R01 NS053907-13/NS/NINDS NIH HHS; R01 NS053907-14/NS/NINDS NIH HHS
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