Document Detail


Deficits in functional connectivity of hippocampal and frontal lobe circuits after traumatic axonal injury.
MedLine Citation:
PMID:  21220676     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To examine the functional connectivity of hippocampal and selected frontal lobe circuits in patients with traumatic axonal injury (TAI).
DESIGN: Observational study.
SETTING: An inpatient traumatic brain injury unit. Imaging and neurocognitive assessments were conducted in an outpatient research facility.
PARTICIPANTS: Twenty-five consecutive patients with brain injuries consistent with TAI and acute subcortical white matter abnormalities were studied as well as 16 healthy volunteers of similar age and sex.
INTERVENTIONS: Echo-planar and high-resolution T1-weighted images were acquired using 3-T scanners. Regions of interest (ROI) were drawn bilaterally for the hippocampus, anterior cingulate cortex (ACC), and dorsolateral prefrontal cortex and were used to extract time series data. Blood oxygenation level-dependent data from each ROI were used as reference functions for correlating with all other brain voxels. Interhemispheric functional connectivity was assessed for each participant by correlating homologous regions using a Pearson correlation coefficient. Patient functional and neurocognitive outcomes were assessed approximately 6 months after injury.
MAIN OUTCOME MEASURES: Interhemispheric functional connectivity, spatial patterns of functional connectivity, and associations of connectivity measures with functional and neurocognitive outcomes.
RESULTS: Patients showed significantly lower interhemispheric functional connectivity for the hippocampus and ACC. Controls demonstrated stronger and more focused functional connectivity for the hippocampi and ACC, and a more focused recruitment of the default mode network for the dorsolateral prefrontal cortex ROI. The interhemispheric functional connectivity for the hippocampus was correlated with delayed recall of verbal information.
CONCLUSIONS: Traumatic axonal injury may affect interhemispheric neural activity, as patients with TAI show disrupted interhemispheric functional connectivity. More careful investigation of interhemispheric connectivity is warranted, as it demonstrated a modest association with outcome in chronic TBI.
Authors:
Carlos D Marquez de la Plata; Juanita Garces; Ehsan Shokri Kojori; Jack Grinnan; Kamini Krishnan; Rajesh Pidikiti; Jeffrey Spence; Michael D Devous; Carol Moore; Rodderick McColl; Christopher Madden; Ramon Diaz-Arrastia
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Archives of neurology     Volume:  68     ISSN:  1538-3687     ISO Abbreviation:  Arch. Neurol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-11     Completed Date:  2011-02-14     Revised Date:  2013-07-02    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  74-84     Citation Subset:  AIM; IM    
Affiliation:
Center for Brain Health, University of Texas at Dallas, Richardson, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Brain Injuries / metabolism*,  pathology,  physiopathology
Diffuse Axonal Injury / metabolism*,  pathology*,  physiopathology
Female
Frontal Lobe / metabolism*,  pathology,  physiopathology
Hippocampus / metabolism*,  pathology,  physiopathology
Humans
Magnetic Resonance Imaging / methods
Male
Middle Aged
Nerve Net / metabolism*,  pathology,  physiopathology
Young Adult
Grant Support
ID/Acronym/Agency:
K23 NS060827/NS/NINDS NIH HHS; K23 NS060827-04/NS/NINDS NIH HHS; R01 HD48179/HD/NICHD NIH HHS
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