Document Detail


Deficits in subprocesses of visual feature search after frontal, parietal, and temporal brain lesions--a modeling approach.
MedLine Citation:
PMID:  19445605     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Deficits in visuospatial attention are commonly observed after different kinds of brain lesions. However, the structure-function relationships are not well understood. We investigated whether our response time (RT) model, strategies of visual search (STRAVIS), combined with a linear model of brain lesions, enables us to relate specific impairments in cognitive processes to specific sites of focal brain lesions. In STRAVIS, RTs in overt visual feature search with graded target-distractor similarity are decomposed into the durations of successive search steps. Fitting the model to an observer's RTs yields individual estimates of the parameters "attentional focus size," "attentional dwell time," and "movement time of attention or the eyes." In 28 patients with various focal lesions to the frontal, parietal, and/or temporal cortex and 28 matched controls, we determined with the help of linear models which lesions were most predictive for each parameter. Predictions were validated with a second sample of 12 patients and 12 controls. Critical lesion areas for the STRAVIS focus size were the dorsolateral prefrontal cortex and the temporal lobe, with dorsolateral prefrontal cortex lesions reducing the focus and temporal lesions enlarging it. The STRAVIS dwell time was reduced in patients with lesions to the anterior insula and the superior parietal lobe. Lesions to the frontal eye fields, the superior parietal lobe, and the parieto-occipital cortex were most detrimental to the STRAVIS movement time. Applying linear models to a patient sample with heterogeneous lesions may be a promising new method for investigating how different brain areas interplay in a complex task.
Authors:
Gisela Müller-Plath; Derek V M Ott; Stefan Pollmann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cognitive neuroscience     Volume:  22     ISSN:  1530-8898     ISO Abbreviation:  J Cogn Neurosci     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-04-06     Completed Date:  2010-08-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8910747     Medline TA:  J Cogn Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1399-424     Citation Subset:  IM    
Affiliation:
Martin-Luther-University Halle-Wittenberg, Halle, Germany. gisela.mueller-plath@psych.uni-halle.de
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MeSH Terms
Descriptor/Qualifier:
Attention / physiology*
Brain Diseases / physiopathology*
Cognition / physiology*
Female
Frontal Lobe / pathology,  physiology*
Humans
Linear Models
Male
Models, Neurological*
Occipital Lobe / physiology*
Parietal Lobe / pathology,  physiology*
Photic Stimulation
Reaction Time
Space Perception / physiology*
Temporal Lobe / pathology,  physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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