| Deficit in nitric oxide production in cirrhotic rat livers is located in the sinusoidal and postsinusoidal areas. | |
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MedLine Citation:
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PMID: 12490431 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intrahepatic nitric oxide (NO) production is decreased in cirrhotic livers. Our objective was to identify, in cirrhotic rat livers, intrahepatic vascular segments where the deficit of NO facilitates the effect of vasoconstrictors. By using a modified rat liver perfusion system with measurement of both the perfusion and sinusoidal (wedged hepatic vein) pressures, we studied the effect of the NO synthase blocker N(omega)-nitro-l-arginine (l-NNA) on the response to methoxamine (alpha(1)-adrenoreceptor agonist) in different segments of the intrahepatic circulation of normal and cirrhotic rat livers. l-NNA enhanced the presinusoidal, sinusoidal, and postsinusoidal responses to methoxamine in normal livers as well as the presinusoidal response in cirrhotic livers. However, l-NNA did not change the already enhanced sinusoidal/postsinusoidal response to methoxamine in cirrhotic livers. The postsinusoidal response to methoxamine was higher in cirrhotic rats with ascites than in those without ascites. We concluded that NO modulates the presinusoidal, sinusoidal, and postsinusoidal vascular tone in normal livers. NO production in cirrhotic rat livers is severely impaired in the sinusoidal and postsinusoidal areas but is preserved in the presinusoidal area, as evidenced by its normal response to l-NNA. We speculate that an increased postsinusoidal response to catecholamines may participate in the genesis of ascites in cirrhosis. |
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Authors:
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Mauricio R Loureiro-Silva; Gregory W Cadelina; Roberto J Groszmann |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2002-12-18 |
Journal Detail:
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Title: American journal of physiology. Gastrointestinal and liver physiology Volume: 284 ISSN: 0193-1857 ISO Abbreviation: Am. J. Physiol. Gastrointest. Liver Physiol. Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-03-12 Completed Date: 2003-04-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100901227 Medline TA: Am J Physiol Gastrointest Liver Physiol Country: United States |
Other Details:
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Languages: eng Pagination: G567-74 Citation Subset: IM |
Affiliation:
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Digestive Diseases Section, Yale University School of Medicine, New Haven 06520, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Agonists
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pharmacology Animals Enzyme Inhibitors / pharmacology Liver Circulation / drug effects, physiology* Liver Cirrhosis / metabolism* Male Methoxamine / pharmacology Microcirculation / drug effects, physiology Nitric Oxide / biosynthesis* Nitric Oxide Synthase / antagonists & inhibitors, metabolism Nitroarginine / pharmacology Rats Rats, Sprague-Dawley Vasoconstriction / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Agonists; 0/Enzyme Inhibitors; 10102-43-9/Nitric Oxide; 2149-70-4/Nitroarginine; 390-28-3/Methoxamine; EC 1.14.13.39/Nitric Oxide Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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