| Deficit of Gammadelta T Lymphocytes in the Peripheral Blood of Patients with Crohn's Disease. | |
| | |
MedLine Citation:
|
PMID: 21374064 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: Gammadelta T lymphocytes are an important component of innate immunity. Previous studies have shown their role in the development of Crohn's-like colitis in mice. AIMS: The aim of this study was to measure the γδ T lymphocyte levels in Crohn's disease (CD) patients. METHODS: A prospective study of 40 patients with CD compared with 40 healthy subjects (control group) matched by age and sex was undertaken. Lennard-Jones criteria were used for the diagnosis of CD. Disease activity was measured with the Crohn's disease activity index (CDAI). New patients, patients in remission, and patients with active disease were evaluated. Lymphocytic populations of CD3+, CD4+, CD8+, CD56+, CD19+, and αβ and γδ subsets were measured in the peripheral blood of all participants. RESULTS: The levels of CD3+, CD4+, CD8+, and CD19+ lymphocytes were decreased in CD patients compared with the control group (P = 0.002, 0.049, 0.003, and 0.023, respectively). Although both γδ and αβ T lymphocytes were lower in patients with CD, γδ T subsets showed the lowest levels in CD patients (mean 0.0259 × 10(9)/l) versus healthy controls (mean 0.0769 × 10(9)/l), P < 0.001. In particular, γδ CD8+ T subsets (mean 0.0068 × 10(9)/l) had the largest difference compared to the control group (mean 0.0199 × 10(9)/l), P = 0.008. CONCLUSIONS: There is a decrease in the global lymphocyte population in the peripheral blood of patients with CD compared to healthy controls. This decrease is more evident in γδ T lymphocytes, especially γδ CD8+ T subsets. Our conclusion is that these results support the theory that a complex alteration of immune responses that affects the total numbers and function of γδ T cells is present in CD. |
| | |
Authors:
|
Juan Carlos Andreu-Ballester; Victoria Amigó-García; Ignacio Catalán-Serra; Rafael Gil-Borrás; Ferrán Ballester; Amadeo Almela-Quilis; Monica Millan-Scheiding; Carlos Peñarroja-Otero |
Related Documents
:
|
9923874 - Non-invasive diagnosis of venous thromboembolism in outpatients. 10759014 - Risk of major bleeding in unselected patients with venous thromboembolism. 20108074 - Prevalence of venous thromboembolism in neurosurgical patients. 20079524 - Combined use of d-dimer and p-selectin for the diagnosis of splenic or portal vein thro... 22567614 - Characterization of a posed smile and evaluation of facial attractiveness by panel perc... 18577344 - Cardiovascular system disease in youth patients with various forms of glucose metabolis... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-5 |
Journal Detail:
|
Title: Digestive diseases and sciences Volume: - ISSN: 1573-2568 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-4 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Research Unit, Emergency Department, Arnau de Vilanova Hospital, c/San Clemente 12, 46015, Valencia, Spain, jcandreu@ono.com. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A Role of the Aryl Hydrocarbon Receptor in Attenuation of Colitis.
Next Document: Pharmacologic Evaluation of Sulfasalazine, FTY720, and Anti-IL-12/23p40 in a TNBS-Induced Crohn's Di...