| Deficient repair of DNA lesion O6-methylguanine in cirrhosis. | |
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MedLine Citation:
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PMID: 8093500 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cirrhosis is a risk factor for hepatocellular carcinoma. O6-methylguanine is a promutagenic and potentially carcinogenic DNA lesion produced by environmental alkylating agents. If it is not repaired, DNA replication can lead to a G-to-A transition mutation, which is a known mechanism of oncogene activation. We have found that the activity of the repairing methyltransferase enzyme is significantly lower in cirrhotic tissue than in non-cirrhotic diseased liver or in normal liver. This finding suggests a mechanism for cirrhosis being a risk factor for cancer of the liver: increased cellular proliferation together with persistence of O6-methylguanine might lead to malignant transformation of liver cells through mutation and oncogene activation. |
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Authors:
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J D Collier; K Guo; A D Burt; M F Bassendine; G N Major |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Lancet Volume: 341 ISSN: 0140-6736 ISO Abbreviation: Lancet Publication Date: 1993 Jan |
Date Detail:
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Created Date: 1993-02-11 Completed Date: 1993-02-11 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985213R Medline TA: Lancet Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 207-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Medical School, University of Newcastle upon Tyne, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biopsy Carcinoma, Hepatocellular / epidemiology, etiology Causality Cell Division Cell Transformation, Neoplastic DNA Repair* Evaluation Studies as Topic Guanine / analogs & derivatives*, chemistry Humans Liver Cirrhosis / blood, complications, pathology* Liver Diseases / blood, classification, pathology* Liver Neoplasms / epidemiology, etiology Lymphocytes / chemistry* Mutagenesis Risk Factors |
| Chemical | |
Reg. No./Substance:
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20535-83-5/O-(6)-methylguanine; 73-40-5/Guanine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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