Document Detail


Deficient quantitative expression of CD45 isoforms on CD4+ and CD8+ T cell subpopulations and subsets of CD45RA(low)CD45RO(low) T cells in newborn blood.
MedLine Citation:
PMID:  8713658     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Deficiencies in the quantitative expression of CD45RA and CD45RO on CD4+ and CD8+ T cells and in a population of CD45RA(low)CD45RO(low) T cells in blood from term newborn infants were found by flow cytometry. The relative frequencies of CD45RO on CD4+ T cells from adults and newborn infants were 72 and 58%, respectively. However, in newborn infants greater than 70% of T cells expressing CD45RO also expressed CD45RA. In addition, the quantitative expression of CD45RA and CD45RO on newborn T cells was significantly less than that found on adult blood T cells.
Authors:
S Chheda; K H Palkowetz; D K Rassin; A S Goldman
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biology of the neonate     Volume:  69     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1996  
Date Detail:
Created Date:  1996-09-19     Completed Date:  1996-09-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  128-32     Citation Subset:  IM; X    
Affiliation:
Department of Pediatrics, University of Texas Medical Branch, Galveston 77555-0526, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antigens, CD45 / biosynthesis*,  blood,  chemistry
CD4-Positive T-Lymphocytes / immunology*
CD8-Positive T-Lymphocytes / immunology*
Fetal Blood / cytology
Flow Cytometry
Humans
Infant, Newborn
T-Lymphocyte Subsets / immunology*
Chemical
Reg. No./Substance:
EC 3.1.3.48/Antigens, CD45

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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