Document Detail


Deficiency and supplementation of PUFA in the diet have similar effects on the age-associated changes in rat-plasma cholesterol levels.
MedLine Citation:
PMID:  18929595     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Levels of plasma cholesterol, particularly LDL cholesterol, increase with increasing age in humans and rodents. Feeding a fish oil-rich diet may exert hypocholesterolemic effects. The aim of this work was to examine the effects of a life-long administration of a PUFA-enriched diet and of a PUFA-deficient diet in male Sprague-Dawley rats on the age-associated increases in plasma cholesterol and triglycerides. Diet had small effects on body-weight, and had dramatic effects on liver phospholipids-fatty acids. Surprisingly, both diets counteracted the age-associated changes in plasma cholesterol and triglycerides similarly and benefits were already visible in adult rats.
Authors:
Sara Straniero; Gabriella Cavallini; Alessio Donati; Maria Rita Metelli; Ilaria Tamburini; Pietro Pietrini; Ettore Bergamini
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Publication Detail:
Type:  Journal Article     Date:  2008-09-25
Journal Detail:
Title:  Mechanisms of ageing and development     Volume:  129     ISSN:  0047-6374     ISO Abbreviation:  Mech. Ageing Dev.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-08     Completed Date:  2009-03-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0347227     Medline TA:  Mech Ageing Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  759-62     Citation Subset:  IM    
Affiliation:
Centro di Ricerca di Biologia e Patologia dell'Invecchiamento, Università di Pisa, via Roma 55, 56126 Pisa, Italy.
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MeSH Terms
Descriptor/Qualifier:
Aging / blood*
Animals
Cholesterol / blood*
Dietary Fats, Unsaturated / administration & dosage*
Fatty Acids / chemistry,  metabolism
Fatty Acids, Unsaturated / administration & dosage*
Liver / metabolism
Male
Phospholipids / chemistry,  metabolism
Rats
Rats, Sprague-Dawley
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Dietary Fats, Unsaturated; 0/Fatty Acids; 0/Fatty Acids, Unsaturated; 0/Phospholipids; 0/Triglycerides; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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