Document Detail

Deficiency of serum concentration of 25-hydroxyvitamin D in psoriatic patients: a case-control study.
MedLine Citation:
PMID:  22387034     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Some autoimmune conditions have been associated with reduced vitamin D levels, including systemic lupus erythematosus, rheumatoid arthritis, diabetes mellitus, and multiple sclerosis.
OBJECTIVE: The main objective of this study was to analyze the 25-hydroxyvitamin D (OHD) status of patients with psoriasis in comparison with control subjects without this disease.
METHODS: This case-control study included 86 patients (43 with psoriasis and 43 age- and sex-matched control subjects) from the outpatient clinic of our hospital dermatology department in Granada, Spain. All patients and control subjects were studied during one 4-week period to avoid seasonal variations in vitamin D levels.
RESULTS: Serum 25-OHD levels were significantly lower in psoriatic patients than in control subjects even after adjusting for confounding factors in a multivariate analysis (odds ratio 2.89, 95% confidence interval 1.02-7.64, P < .03 for vitamin D insufficiency). Low 25-OHD levels were negatively associated with C-reactive protein (inflammatory activation marker) and body mass index in multiple linear regression analysis. Psoriatic patients with body mass index greater than or equal to 27 kg/m(2) had a higher risk of 25-OHD insufficiency (sensitivity of 82.3% and specificity of 51.7%).
LIMITATIONS: Further studies with larger numbers of patients are required to analyze the pathogenic mechanisms underlying the relationship between 25-OHD deficiency and psoriasis.
CONCLUSIONS: The 25-OHD values are significantly lower in psoriatic patients than in control subjects. Low 25-OHD levels are negatively associated with C-reactive protein, an inflammatory activation marker, and with obesity. Psoriatic patients with a body mass index of 27 or more are likely to have vitamin D insufficiency.
Jacinto Orgaz-Molina; Agustín Buendía-Eisman; Miguel A Arrabal-Polo; José Carlos Ruiz; Salvador Arias-Santiago
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Publication Detail:
Type:  Journal Article     Date:  2012-03-02
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  67     ISSN:  1097-6787     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-15     Completed Date:  2013-01-17     Revised Date:  2013-03-21    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  931-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
Dermatology Department, San Cecilio University Hospital, Granada, Spain.
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MeSH Terms
Body Mass Index
C-Reactive Protein / analysis
Case-Control Studies
Hydroxycholecalciferols / blood*
Logistic Models
Multivariate Analysis
Obesity / epidemiology
Psoriasis / blood*,  epidemiology*
ROC Curve
Sensitivity and Specificity
Vitamin D Deficiency / epidemiology*
Reg. No./Substance:
0/Hydroxycholecalciferols; 9007-41-4/C-Reactive Protein
Comment In:
J Am Acad Dermatol. 2013 Mar;68(3):511-2   [PMID:  23394917 ]

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