| Deficiency of selenium intake enhances manifestation of renal toxicity of cis-diamminedichloroplatinum in mice. | |
| | |
MedLine Citation:
|
PMID: 3629626 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effect of the dietary level of selenium on lethal and renal toxicity of cis-diamminedichloroplatinum (cis-DDP) was investigated using mice fed diets containing 4 different concentrations of selenium (0.009, 0.1, 0.4 or 1.0 ppm) for 6 weeks starting at 4 weeks of age. The groups of mice fed the diets containing 0.009 and 0.1 ppm of selenium showed higher sensitivity to the lethal toxicity caused by a single subcutaneous administration of cis-DDP (32 mumol/kg) than the other groups. The renal toxicity of cis-DDP, indicated by increases in blood urea nitrogen (BUN), serum creatinine and urinary activity of N-acetylglucosaminidase (NAG), was significantly enhanced by a decrease in dietary selenium level. These results suggest that the dietary level of selenium affects the manifestation of lethal and renal toxicity of cis-DDP. |
| | |
Authors:
|
M Satoh; A Naganuma; N Imura |
Related Documents
:
|
14608056 - Dietary selenium intake modulates thyroid hormone and energy metabolism in men. 9465776 - Giving selenium supplements to dairy cows strengthens the inflammatory response to intr... 12396466 - Effect of squalene and shark liver oil on serum cholesterol level in hamsters. 9403136 - Bioavailability of rumen bacterial selenium in mice using tissue uptake technique. 2611086 - Codeine o-demethylation co-segregates with polymorphic debrisoquine hydroxylation. 8708106 - Response of early lactation cows to ruminally undegradable protein in the diet. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Toxicology letters Volume: 38 ISSN: 0378-4274 ISO Abbreviation: Toxicol. Lett. Publication Date: 1987 Sep |
Date Detail:
|
Created Date: 1987-10-08 Completed Date: 1987-10-08 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7709027 Medline TA: Toxicol Lett Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 155-60 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acetylglucosaminidase
/
urine Animals Blood Urea Nitrogen Cisplatin / antagonists & inhibitors, toxicity* Creatinine / metabolism Injections, Subcutaneous Kidney / drug effects* Male Mice Selenium / deficiency*, pharmacology |
| Chemical | |
Reg. No./Substance:
|
15663-27-1/Cisplatin; 60-27-5/Creatinine; 7782-49-2/Selenium; EC 3.2.1.52/Acetylglucosaminidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Binding of formaldehyde to human and rat nasal mucus and bovine serum albumin.
Next Document: Acetone effects on N-(3,5-dichlorophenyl)succinimide-induced nephrotoxicity.