| Deficiency of S-adenosylmethionine-homocysteine methyltransferase activity in hepatoma cells. | |
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MedLine Citation:
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PMID: 187333 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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S-Adenosylmethionine-homocysteine methyltransferase, which catalyzes synthesis of methionine from homocysteine, with the use of S-adenosylmethionine as the methyl donor, is absent in tumor tissue such as rat ascites hepatoma and Morris hepatoma but is present in rat liver homogenate. Absence of the enzymatic activity in tumor cells is not due to the action of an inhibitor. S-Adenosylhomocysteine hydrolase, however, is present in both rat liver and hepatoma tissue. |
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Authors:
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Y Kuchino; T Yasuda; S Nishimura |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cancer research Volume: 37 ISSN: 0008-5472 ISO Abbreviation: Cancer Res. Publication Date: 1977 Jan |
Date Detail:
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Created Date: 1977-02-26 Completed Date: 1977-02-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 206-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carcinoma, Hepatocellular / enzymology* Female Homocysteine / metabolism* Hydrolases / metabolism Liver / enzymology Liver Neoplasms / enzymology* Methyltransferases / deficiency* Neoplasms, Experimental / enzymology Rats S-Adenosylhomocysteine / metabolism S-Adenosylmethionine / metabolism* |
| Chemical | |
Reg. No./Substance:
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29908-03-0/S-Adenosylmethionine; 454-28-4/Homocysteine; 979-92-0/S-Adenosylhomocysteine; EC 2.1.1.-/Methyltransferases; EC 3.-/Hydrolases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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