Document Detail

Deficiencies of polyunsaturated fatty acids and replacement by nonessential fatty acids in plasma lipids in multiple sclerosis.
MedLine Citation:
PMID:  2734316     Owner:  NLM     Status:  MEDLINE    
Fatty acid compositions of plasma phospholipids, cholesteryl esters, triacylglycerols, and nonesterified fatty acids of 14 clinically proven and graded cases of multiple sclerosis were determined by capillary gas chromatography and compared with the values obtained for 100 normal, healthy subjects. In phospholipids, linoleic acid (18:2 omega 6; 18 carbon atoms, 2 double bonds, 6 carbon atoms beyond last double bond) was normal and 18:3 omega 6 was increased, but all subsequent omega 6 acids were subnormal (P less than 0.001), indicating impairment of chain elongation. All omega 3 acids were subnormal. The paucity of polyunsaturated fatty acids was compensated mass-wise by an increase in saturated acids. Disproportionate increases in short-chain, saturated, and monounsaturated acids, decreases in long-chain homologs, and increases of branched and odd-chain acids were observed. Loss of polyunsaturated fatty acids and replacement by nonessential acids lowered mean chain length and raised mean melting point significantly, suggesting that lowered membrane fluidity was only partially compensated by endogenous synthesis of lower-melting, nonessential acids. This phenomenon was not observed in cholesteryl esters or triacylglycerols. Nonesterified fatty acids showed significant changes in pattern of possible autacoid precursors. The abnormal profile of fatty acids in multiple sclerosis has features in common with profiles of other syndromes involving viral infections.
R T Holman; S B Johnson; E Kokmen
Related Documents :
8810066 - Absorption of short-chain fatty acids across ruminal epithelium of sheep.
11791846 - Tracing sewage in the marine environment: altered signatures in concepción bay, chile.
409896 - Antimicrobial lipids: natural and synthetic fatty acids and monoglycerides.
11371536 - Unusual methyl-branched alpha,beta-unsaturated acyl chain substitutions in the nod fact...
15291496 - Antioxidant phenols in barley (hordeum vulgare l.) flour: comparative spectrophotometri...
1280806 - Structure determination of two new amino acid-containing derivatives of adenosine from ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  86     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-07-21     Completed Date:  1989-07-21     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  4720-4     Citation Subset:  IM    
Hormel Institute, University of Minnesota, Austin 55912.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cholesterol Esters / blood
Fatty Acids, Nonesterified / blood*
Fatty Acids, Unsaturated / blood*,  deficiency
Lipids / blood*
Middle Aged
Multiple Sclerosis / blood*
Phospholipids / blood
Reference Values
Triglycerides / blood
Grant Support
Reg. No./Substance:
0/Cholesterol Esters; 0/Fatty Acids, Nonesterified; 0/Fatty Acids, Unsaturated; 0/Lipids; 0/Phospholipids; 0/Triglycerides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Coamplification of human acetylcholinesterase and butyrylcholinesterase genes in blood cells: correl...
Next Document:  A cell line producing recombinant nerve growth factor evokes growth responses in intrinsic and graft...