Document Detail


Deficiencies of polyunsaturated fatty acids and replacement by nonessential fatty acids in plasma lipids in multiple sclerosis.
MedLine Citation:
PMID:  2734316     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fatty acid compositions of plasma phospholipids, cholesteryl esters, triacylglycerols, and nonesterified fatty acids of 14 clinically proven and graded cases of multiple sclerosis were determined by capillary gas chromatography and compared with the values obtained for 100 normal, healthy subjects. In phospholipids, linoleic acid (18:2 omega 6; 18 carbon atoms, 2 double bonds, 6 carbon atoms beyond last double bond) was normal and 18:3 omega 6 was increased, but all subsequent omega 6 acids were subnormal (P less than 0.001), indicating impairment of chain elongation. All omega 3 acids were subnormal. The paucity of polyunsaturated fatty acids was compensated mass-wise by an increase in saturated acids. Disproportionate increases in short-chain, saturated, and monounsaturated acids, decreases in long-chain homologs, and increases of branched and odd-chain acids were observed. Loss of polyunsaturated fatty acids and replacement by nonessential acids lowered mean chain length and raised mean melting point significantly, suggesting that lowered membrane fluidity was only partially compensated by endogenous synthesis of lower-melting, nonessential acids. This phenomenon was not observed in cholesteryl esters or triacylglycerols. Nonesterified fatty acids showed significant changes in pattern of possible autacoid precursors. The abnormal profile of fatty acids in multiple sclerosis has features in common with profiles of other syndromes involving viral infections.
Authors:
R T Holman; S B Johnson; E Kokmen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  86     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-07-21     Completed Date:  1989-07-21     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  4720-4     Citation Subset:  IM    
Affiliation:
Hormel Institute, University of Minnesota, Austin 55912.
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MeSH Terms
Descriptor/Qualifier:
Adult
Cholesterol Esters / blood
Fatty Acids, Nonesterified / blood*
Fatty Acids, Unsaturated / blood*,  deficiency
Female
Humans
Lipids / blood*
Male
Middle Aged
Multiple Sclerosis / blood*
Phospholipids / blood
Reference Values
Triglycerides / blood
Grant Support
ID/Acronym/Agency:
HL08214/HL/NHLBI NIH HHS; NS14304/NS/NINDS NIH HHS; P30-AM34931/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/Cholesterol Esters; 0/Fatty Acids, Nonesterified; 0/Fatty Acids, Unsaturated; 0/Lipids; 0/Phospholipids; 0/Triglycerides
Comments/Corrections

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