Document Detail

Deficiencies in opsonic defense to pneumococci in the human newborn despite adequate levels of complement and specific IgG antibodies.
MedLine Citation:
PMID:  2345679     Owner:  NLM     Status:  MEDLINE    
We studied the major determinants of opsonophagocytosis against Streptococcus pneumoniae serotypes 14 and 19 in paired cord/maternal sera from 27 healthy term and 24 preterm infants in an attempt to gain more insight in the susceptibility of newborns to pneumococcal infection. For both pneumococcal serotypes studied, opsonic activity in neonatal sera varied greatly, but was moderately to profoundly deficient when compared to paired maternal sera, both in preterm (34.5 and 34.9% of the activity in maternal serum, for serotypes 14 and 19, respectively, p less than 0.001 for both) and in term serum (43.5 and 52.7% of the activity in maternal serum, for serotypes 14 and 19, respectively, p less than 0.001 for both). The opsonic deficiency in preterm sera could be ascribed to a diminished level of the major opsonins for pneumococci, i.e. complement factor C3 deposited on the bacterial surface (69.5 and 66.2% of C3 deposition in maternal serum on serotypes 14 and 19, respectively, p less than 0.01 for both) and specific anticapsular IgG antibodies (48.5 and 14.1% of maternal levels for serotypes 14 and 19, respectively, p less than 0.001 for both). However, the opsonic defect in serum from term infants could not be explained in a similar way, because C3 deposition and specific anticapsular IgG levels were equal to the values found in the paired maternal sera. Therefore, we conclude that the opsonic defect in newborn serum for pneumococci cannot be solely explained by a deficiency in the major opsonins for these bacteria. A dysfunction in these opsonins seems to be a more likely explanation for the observed opsonic defect in the neonate.
S P Geelen; A Fleer; A C Bezemer; L J Gerards; G T Rijkers; J Verhoef
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric research     Volume:  27     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-06-29     Completed Date:  1990-06-29     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  514-8     Citation Subset:  IM    
Department of Infectious Diseases, University Children's Hospital Het Wilhelmina Kinderziekenhuis, Utrecht, The Netherlands.
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MeSH Terms
Antibodies, Bacterial / analysis,  immunology*
Complement Activation / immunology
Complement C3 / immunology
Disease Susceptibility
Gestational Age
Infant, Newborn
Infant, Premature, Diseases / blood,  immunology*
Maternal-Fetal Exchange
Opsonin Proteins / immunology*
Pneumococcal Infections / blood,  immunology*
Streptococcus pneumoniae / immunology*
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Complement C3; 0/Opsonin Proteins

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