| Deferasirox exposure induces reactive oxygen species and reduces growth and viability of myelodysplastic hematopoietic progenitors. | |
| | |
MedLine Citation:
|
PMID: 22502920 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
We examined the effect of deferasirox (DFX) on CD34+ hematopoietic progenitors from MDS patients. Progressive, dose-dependent suppression of MDS progenitor proliferation in culture was observed with DFX concentrations ranging from 5μM to 20μM. This effect was more pronounced in MDS compared to CD34+ progenitors isolated from umbilical cord blood or normal peripheral blood. There was reduced viability of MDS progenitors but not normal progenitors at 20μM DFX which increased with duration of exposure. Exposure to 20μM DFX for 14days markedly suppressed colony growth of MDS progenitors. Reactive oxygen species levels were elevated above control at concentrations of DFX above 5μM. We conclude that exposure to DFX results in dose-dependent inhibition of proliferation, and survival in MDS progenitors. |
| | |
Authors:
|
Vinod Pullarkat; Arjun Sehgal; Liang Li; Zhuo Meng; Allen Lin; Stephen Forman; Ravi Bhatia |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-4-11 |
Journal Detail:
|
Title: Leukemia research Volume: - ISSN: 1873-5835 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
|
Created Date: 2012-4-16 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7706787 Medline TA: Leuk Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012. Published by Elsevier Ltd. |
Affiliation:
|
Department of Hematology and Hematopoietic Cell Transplantation, City of Hope Medical Center, Duarte, CA, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Basic life support skills of high school students before and after cardiopulmonary resuscitation tra...
Next Document: Public health workforce research in review: a 25-year retrospective.