Document Detail


Defense-like behaviors evoked by pharmacological disinhibition of the superior colliculus in the primate.
MedLine Citation:
PMID:  23283329     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Stimulation of the intermediate and deep layers of superior colliculus (DLSC) in rodents evokes both orienting/pursuit (approach) and avoidance/flight (defense) responses (Dean et al., 1989). These two classes of response are subserved by distinct output projections associated with lateral (approach) and medial (defense) DLSC (Comoli et al., 2012). In non-human primates, DLSC has been examined only with respect to orienting/approach behaviors, especially eye movements, and defense-like behaviors have not been reported. Here we examined the profile of behavioral responses evoked by activation of DLSC by unilateral intracerebral infusions of the GABA(A) receptor antagonist, bicuculline methiodide (BIC), in nine freely moving macaques. Across animals, the most consistently evoked behavior was cowering (all animals), followed by increased vocalization and escape-like behaviors (seven animals), and attack of objects (three animals). The effects of BIC were dose-dependent within the range 2.5-14 nmol (threshold dose of 4.6 nmol). The behaviors and their latencies to onset did not vary across different infusion sites within DLSC. Cowering and escape-like behaviors resembled the defense-like responses reported after DLSC stimulation in rats, but in the macaques these responses were evoked from both medial and lateral sites within DLSC. Our findings are unexpected in the context of an earlier theoretical perspective (Dean et al., 1989) that emphasized a preferential role of the primate DLSC for approach rather than defensive responses. Our data provide the first evidence for induction of defense-like behaviors by activation of DLSC in monkeys, suggesting that the role of DLSC in responding to threats is conserved across species.
Authors:
Jacqueline T DesJardin; Angela L Holmes; Patrick A Forcelli; Claire E Cole; John T Gale; Laurie L Wellman; Karen Gale; Ludise Malkova
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  33     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-03     Completed Date:  2013-03-12     Revised Date:  2013-07-18    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  150-5     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC 20007, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Animal / drug effects*,  physiology
Bicuculline / pharmacology
Dose-Response Relationship, Drug
Female
GABA-A Receptor Antagonists / pharmacology
Macaca mulatta
Macaca nemestrina
Male
Neurons / drug effects*,  physiology
Superior Colliculi / drug effects*,  physiology
Vocalization, Animal / drug effects*,  physiology
Grant Support
ID/Acronym/Agency:
F31 NS061623/NS/NINDS NIH HHS; F31NS061623/NS/NINDS NIH HHS; R01 MH084069/MH/NIMH NIH HHS; R01 NS020576/NS/NINDS NIH HHS; R01MH82364/MH/NIMH NIH HHS; R01NS020576/NS/NINDS NIH HHS; R21 HD039937/HD/NICHD NIH HHS; R21HD039937/HD/NICHD NIH HHS; T32 HD007459/HD/NICHD NIH HHS; T32HD007459/HD/NICHD NIH HHS; //Howard Hughes Medical Institute
Chemical
Reg. No./Substance:
0/GABA-A Receptor Antagonists; 485-49-4/Bicuculline
Comments/Corrections

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