Document Detail

Defects of leukocyte migration in primary immunodeficiencies.
MedLine Citation:
PMID:  23630104     Owner:  NLM     Status:  MEDLINE    
This Viewpoint gives an overview of the inherited disorders that are characterized by defects of leukocyte trafficking. Three paradigmatic diseases have been selected: warts, hypogammaglobulinemia, infections, and myelokathexis; Wiskott-Aldrich; and leukocyte adhesion deficiency syndromes. These conditions encompass defects in the steps that are required for leukocyte motility: from the response to chemokines, which is altered in warts, hypogammaglobulinemia, infections, and myelokathexis syndrome, to the impairment of leukocyte adhesion and migration found in leukocyte adhesion deficiency syndrome, and finally to abnormal actin filament formation, which is affected in leukocytes of Wiskott-Aldrich syndrome patients.
Raffaele Badolato
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  European journal of immunology     Volume:  43     ISSN:  1521-4141     ISO Abbreviation:  Eur. J. Immunol.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-06-21     Completed Date:  2013-09-06     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  1273201     Medline TA:  Eur J Immunol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1436-40     Citation Subset:  IM    
Copyright Information:
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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MeSH Terms
Cell Adhesion / genetics,  immunology
Cell Movement / genetics,  immunology
Chemotaxis / genetics
Cytoskeleton / genetics,  immunology*
Immunologic Deficiency Syndromes / genetics,  immunology*
Leukocytes / immunology*
Warts / genetics,  immunology*
Grant Support

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