| Defects in pokeweed mitogen (PWM) induced immunoglobulin (Ig) synthesis by lymphocytes of patients with juvenile rheumatoid arthritis. | |
| | |
MedLine Citation:
|
PMID: 4057196 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In vitro pokeweed mitogen (PWM) induced immunoglobulin (Ig) synthesis by lymphocytes of 33 patients with juvenile rheumatoid arthritis (JRA) was assessed and the results were correlated with clinical characteristics and laboratory measurements of disease activity. Comparisons with results of lymphocytes from adult controls and age related controls, greater than or equal to 12 years, showed reduced responses in patients with JRA. Low responders had significantly higher sedimentation rates (p = .0052) and platelet counts (p = .033), than patients with normal results. No correlations with onset subtype, medications, or age were found. These findings suggest a reduction in in vitro PWM induced B cell differentiation in patients with JRA, which may be related to disease activity. |
| | |
Authors:
|
K Oen |
Related Documents
:
|
7053826 - The in vitro effect of a calf thymus extract (thymostimulin) on the immunologic paramet... 2912606 - Lymphocyte subsets in acute rheumatic fever and rheumatic heart disease. 20972816 - Blood lymphocyte blastogenesis in patients with thyroid dysfunction: ex vivo response ... 19073006 - Tumor-derived microvesicles in sera of patients with head and neck cancer and their rol... 17986526 - Comparison of long-term survival (beyond 12 years) in patients on peritoneal dialysis a... 18431816 - Meg recordings of patients with cns disorders before and after external magnetic stimul... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Journal of rheumatology Volume: 12 ISSN: 0315-162X ISO Abbreviation: J. Rheumatol. Publication Date: 1985 Aug |
Date Detail:
|
Created Date: 1985-12-05 Completed Date: 1985-12-05 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7501984 Medline TA: J Rheumatol Country: CANADA |
Other Details:
|
Languages: eng Pagination: 728-34 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Arthritis, Juvenile Rheumatoid / metabolism*, pathology, physiopathology Cells, Cultured Child Humans Immunoglobulins / biosynthesis* Lymphocytes / classification, metabolism* Middle Aged Pokeweed Mitogens / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Immunoglobulins; 0/Pokeweed Mitogens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The Raji cell radioimmunoassay in patients with systemic lupus erythematosus: clinical significance ...
Next Document: The effect of antiinflammatory drugs on plasma fibronectin.