| Defective regulation of chemotaxis in cirrhosis. | |
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MedLine Citation:
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PMID: 1120929 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The presence of a severe leukotactic defect in cirrhotic patients has been confirmed. This defect is due to the presence of abnormally high levels of the chemotactic factor inactivator (CFI) in serums of patients with hepatic cirrhosis. This inactivator inhibits each of three different chemotactic factors tested and does so in an irreversible manner. As would be predicted by these results, generation of chemotactic activity in cirrhotic serums by a complement-activating agent is markedly impaired. Physicochemical features of CFI in cirrhotic serum differ slightly from that found in normal human serum. These results indicate the nature of the chemotactic defect in cirrhotic patients and may explain the increased susceptibility of these patients to bacterial infections and some of their reported defected in expression of cellular immunity. |
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Authors:
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E C Maderazo; P A Ward; R Quintiliani |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of laboratory and clinical medicine Volume: 85 ISSN: 0022-2143 ISO Abbreviation: J. Lab. Clin. Med. Publication Date: 1975 Apr |
Date Detail:
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Created Date: 1975-06-26 Completed Date: 1975-06-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375375 Medline TA: J Lab Clin Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 621-30 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chemotaxis*
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drug effects Complement System Proteins Depression, Chemical Humans Leukocytes / physiology Liver Cirrhosis / blood*, immunology, pathology Neutrophils / physiology Ultracentrifugation |
| Chemical | |
Reg. No./Substance:
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9007-36-7/Complement System Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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