Document Detail

Defective regulation of chemotaxis in cirrhosis.
MedLine Citation:
PMID:  1120929     Owner:  NLM     Status:  MEDLINE    
The presence of a severe leukotactic defect in cirrhotic patients has been confirmed. This defect is due to the presence of abnormally high levels of the chemotactic factor inactivator (CFI) in serums of patients with hepatic cirrhosis. This inactivator inhibits each of three different chemotactic factors tested and does so in an irreversible manner. As would be predicted by these results, generation of chemotactic activity in cirrhotic serums by a complement-activating agent is markedly impaired. Physicochemical features of CFI in cirrhotic serum differ slightly from that found in normal human serum. These results indicate the nature of the chemotactic defect in cirrhotic patients and may explain the increased susceptibility of these patients to bacterial infections and some of their reported defected in expression of cellular immunity.
E C Maderazo; P A Ward; R Quintiliani
Related Documents :
11206869 - Intrapulmonary vascular dilatation in portal hypertension due to cirrhosis of liver.
15884119 - Genetic association of cytokines polymorphisms with autoimmune hepatitis and primary bi...
16512459 - Unconjugated hyperbilirubinemia in nonalcoholic steatohepatitis--is it gilbert's syndrome?
7836699 - Nutritional status in cirrhosis. italian multicentre cooperative project on nutrition i...
22985429 - No ggggcc-hexanucleotide repeat expansion in c9orf72 in parkinsonism patients in sweden.
11870569 - Comparative study of portal hypertensive gastropathy in schistosomiasis and hepatic cir...
23063059 - Intravenous alteplase at 0.6 mg/kg for acute stroke patients with basilar artery occlus...
20190129 - Alteration of delay and trace eyeblink conditioning in fibromyalgia patients.
6168779 - Clinical evaluation of immunological methods for detection for serum prostatic acid pho...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of laboratory and clinical medicine     Volume:  85     ISSN:  0022-2143     ISO Abbreviation:  J. Lab. Clin. Med.     Publication Date:  1975 Apr 
Date Detail:
Created Date:  1975-06-26     Completed Date:  1975-06-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375375     Medline TA:  J Lab Clin Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  621-30     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Chemotaxis* / drug effects
Complement System Proteins
Depression, Chemical
Leukocytes / physiology
Liver Cirrhosis / blood*,  immunology,  pathology
Neutrophils / physiology
Reg. No./Substance:
9007-36-7/Complement System Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Serum dopamine-beta-hydroxylase activity in parents and children.
Next Document:  Studies on crystal-induced chemotactic factor. II. Role of phagocytosis.