Document Detail

Defective regulation of chemotaxis in cirrhosis.
MedLine Citation:
PMID:  1120929     Owner:  NLM     Status:  MEDLINE    
The presence of a severe leukotactic defect in cirrhotic patients has been confirmed. This defect is due to the presence of abnormally high levels of the chemotactic factor inactivator (CFI) in serums of patients with hepatic cirrhosis. This inactivator inhibits each of three different chemotactic factors tested and does so in an irreversible manner. As would be predicted by these results, generation of chemotactic activity in cirrhotic serums by a complement-activating agent is markedly impaired. Physicochemical features of CFI in cirrhotic serum differ slightly from that found in normal human serum. These results indicate the nature of the chemotactic defect in cirrhotic patients and may explain the increased susceptibility of these patients to bacterial infections and some of their reported defected in expression of cellular immunity.
E C Maderazo; P A Ward; R Quintiliani
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of laboratory and clinical medicine     Volume:  85     ISSN:  0022-2143     ISO Abbreviation:  J. Lab. Clin. Med.     Publication Date:  1975 Apr 
Date Detail:
Created Date:  1975-06-26     Completed Date:  1975-06-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375375     Medline TA:  J Lab Clin Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  621-30     Citation Subset:  AIM; IM    
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MeSH Terms
Chemotaxis* / drug effects
Complement System Proteins
Depression, Chemical
Leukocytes / physiology
Liver Cirrhosis / blood*,  immunology,  pathology
Neutrophils / physiology
Reg. No./Substance:
9007-36-7/Complement System Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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