Document Detail

Defective mitogen-induced cellular cytotoxicity in untreated patients with active rheumatoid arthritis.
MedLine Citation:
PMID:  7839069     Owner:  NLM     Status:  MEDLINE    
Peripheral blood mitogen-induced cellular cytotoxicity (MICC) was studied in 13 untreated patients with active rheumatoid arthritis (RA; group A) and in 5 RA patients with inactive disease (group B), using phytohemagglutinin (PHA) as stimulating agent and K562 cells as target cells in the chromium-51 release assay. MICC was found to be significantly reduced in the patients of group A compared with normal subjects (P < 0.01) and the patients of group B (P < 0.05). No differences were noted in MICC between group B patients and normal subjects. A statistically significant negative correlation was found between values of patients' MICC and serum C-reactive protein levels (r = -0.685, P < 0.01). Furthermore, patients' MICC correlated well with patients' peripheral blood natural killer cell activity (P < 0.02), as well as with the absolute number of circulating CD8+ cells. No correlation was found between MICC and duration of disease, erythrocyte sedimentation rate, serum alpha 2-globulins, or the titre of serum rheumatoid factor in the patients studied. We concluded that defective MICC in untreated patients with active RA is probably due to the diminution of the number of CD8+ cells, although a qualitative defect of these cells cannot be excluded.
G Vaiopoulos; D Kyriakou; H Papadaki; P Kaklamanis; G D Eliopoulos
Related Documents :
16826439 - Single-factor scoring validation for the health assessment questionnaire-disability ind...
8299259 - Influence of disease activity on steroid hormone levels in peripheral blood of patients...
3423749 - Work capacity of patients with inflammatory joint diseases. an eight-year follow-up study.
3759149 - Study on the association of hla with pulmonary tuberculosis.
6971489 - Monocyte cytotoxicity in connective tissue diseases. correlation with disease groups.
1782749 - Hla-b40: a marker for susceptibility to lung disease in rheumatoid arthritis.
16826439 - Single-factor scoring validation for the health assessment questionnaire-disability ind...
25424589 - A comparative study of dexmedetomidine and propofol as sole sedative agents for patient...
20059599 - Six-minute walk test: observed adverse events and oxygen desaturation in a large cohort...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Rheumatology international     Volume:  14     ISSN:  0172-8172     ISO Abbreviation:  Rheumatol. Int.     Publication Date:  1994  
Date Detail:
Created Date:  1995-03-02     Completed Date:  1995-03-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8206885     Medline TA:  Rheumatol Int     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  103-7     Citation Subset:  IM    
Laiko General Hospital of Athens, Greece.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Arthritis, Rheumatoid / immunology*
Cytotoxicity Tests, Immunologic
Cytotoxicity, Immunologic / immunology*
Fluorescent Antibody Technique
Interferon-alpha / pharmacology*
Interleukin-2 / pharmacology*
Killer Cells, Natural / drug effects,  immunology*
Middle Aged
T-Lymphocytes / drug effects,  immunology*
Reg. No./Substance:
0/Interferon-alpha; 0/Interleukin-2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Efficacy of slow-release betamethasone in Churg-Strauss syndrome. Apropos of a case
Next Document:  R-h-erythropoietin counteracts the inhibition of in vitro erythropoiesis by tumour necrosis factor a...