Document Detail


Defective mitogen-induced cellular cytotoxicity in untreated patients with active rheumatoid arthritis.
MedLine Citation:
PMID:  7839069     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Peripheral blood mitogen-induced cellular cytotoxicity (MICC) was studied in 13 untreated patients with active rheumatoid arthritis (RA; group A) and in 5 RA patients with inactive disease (group B), using phytohemagglutinin (PHA) as stimulating agent and K562 cells as target cells in the chromium-51 release assay. MICC was found to be significantly reduced in the patients of group A compared with normal subjects (P < 0.01) and the patients of group B (P < 0.05). No differences were noted in MICC between group B patients and normal subjects. A statistically significant negative correlation was found between values of patients' MICC and serum C-reactive protein levels (r = -0.685, P < 0.01). Furthermore, patients' MICC correlated well with patients' peripheral blood natural killer cell activity (P < 0.02), as well as with the absolute number of circulating CD8+ cells. No correlation was found between MICC and duration of disease, erythrocyte sedimentation rate, serum alpha 2-globulins, or the titre of serum rheumatoid factor in the patients studied. We concluded that defective MICC in untreated patients with active RA is probably due to the diminution of the number of CD8+ cells, although a qualitative defect of these cells cannot be excluded.
Authors:
G Vaiopoulos; D Kyriakou; H Papadaki; P Kaklamanis; G D Eliopoulos
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Rheumatology international     Volume:  14     ISSN:  0172-8172     ISO Abbreviation:  Rheumatol. Int.     Publication Date:  1994  
Date Detail:
Created Date:  1995-03-02     Completed Date:  1995-03-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8206885     Medline TA:  Rheumatol Int     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  103-7     Citation Subset:  IM    
Affiliation:
Laiko General Hospital of Athens, Greece.
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MeSH Terms
Descriptor/Qualifier:
Adult
Arthritis, Rheumatoid / immunology*
Cytotoxicity Tests, Immunologic
Cytotoxicity, Immunologic / immunology*
Female
Fluorescent Antibody Technique
Humans
Interferon-alpha / pharmacology*
Interleukin-2 / pharmacology*
Killer Cells, Natural / drug effects,  immunology*
Male
Middle Aged
T-Lymphocytes / drug effects,  immunology*
Chemical
Reg. No./Substance:
0/Interferon-alpha; 0/Interleukin-2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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