| Defective gap junctional intercellular communication in lung cancer: loss of an important mediator of tissue homeostasis and phenotypic regulation. | |
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MedLine Citation:
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PMID: 11293326 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gap junctions provide direct pathways for the exchange of molecules and ions between neighboring cells, a process known as gap junctional intercellular communication (GJIC). This GJIC is important for homeostasis and regulation of mitosis, differentiation, and apoptosis. Gap junctions are present in lung airway and alveolar epithelial cells and, in addition to the above roles, might coordinate ciliary beating and surfactant secretion. GJIC is decreased in human and mouse lung carcinoma cells because of reduced expression of the gap junction protein, connexin43 (Cx43), and defects in signal transduction pathways that mediate Cx43 function. This reduced GJIC is important in the behavior of lung carcinoma cells because forced expression of Cx43 in lung carcinoma cells inhibits their growth and tumorigenicity. In this report, we summarize our studies on the role of GJIC in lung neoplasia. |
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Authors:
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R J Ruch; S Porter; L D Koffler; L D Dwyer-Nield; A M Malkinson |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Experimental lung research Volume: 27 ISSN: 0190-2148 ISO Abbreviation: Exp. Lung Res. Publication Date: 2001 Apr-May |
Date Detail:
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Created Date: 2001-04-09 Completed Date: 2001-08-02 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8004944 Medline TA: Exp Lung Res Country: United States |
Other Details:
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Languages: eng Pagination: 231-43 Citation Subset: IM |
Affiliation:
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Department of Pathology, Medical College of Ohio, 3055 Arlington Avenue, Toledo, OH 43614, USA. rruch@mco.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Communication / physiology* Connexin 43 / genetics, physiology Gap Junctions / physiology* Gene Expression Gene Therapy Homeostasis Humans Lung Neoplasms / genetics, physiopathology*, therapy Mice Phenotype Transfection Tumor Cells, Cultured |
| Grant Support | |
ID/Acronym/Agency:
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CA33497/CA/NCI NIH HHS; CA57612/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Connexin 43 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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