Document Detail


Defective gap junctional intercellular communication in lung cancer: loss of an important mediator of tissue homeostasis and phenotypic regulation.
MedLine Citation:
PMID:  11293326     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gap junctions provide direct pathways for the exchange of molecules and ions between neighboring cells, a process known as gap junctional intercellular communication (GJIC). This GJIC is important for homeostasis and regulation of mitosis, differentiation, and apoptosis. Gap junctions are present in lung airway and alveolar epithelial cells and, in addition to the above roles, might coordinate ciliary beating and surfactant secretion. GJIC is decreased in human and mouse lung carcinoma cells because of reduced expression of the gap junction protein, connexin43 (Cx43), and defects in signal transduction pathways that mediate Cx43 function. This reduced GJIC is important in the behavior of lung carcinoma cells because forced expression of Cx43 in lung carcinoma cells inhibits their growth and tumorigenicity. In this report, we summarize our studies on the role of GJIC in lung neoplasia.
Authors:
R J Ruch; S Porter; L D Koffler; L D Dwyer-Nield; A M Malkinson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Experimental lung research     Volume:  27     ISSN:  0190-2148     ISO Abbreviation:  Exp. Lung Res.     Publication Date:    2001 Apr-May
Date Detail:
Created Date:  2001-04-09     Completed Date:  2001-08-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8004944     Medline TA:  Exp Lung Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  231-43     Citation Subset:  IM    
Affiliation:
Department of Pathology, Medical College of Ohio, 3055 Arlington Avenue, Toledo, OH 43614, USA. rruch@mco.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Communication / physiology*
Connexin 43 / genetics,  physiology
Gap Junctions / physiology*
Gene Expression
Gene Therapy
Homeostasis
Humans
Lung Neoplasms / genetics,  physiopathology*,  therapy
Mice
Phenotype
Transfection
Tumor Cells, Cultured
Grant Support
ID/Acronym/Agency:
CA33497/CA/NCI NIH HHS; CA57612/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Connexin 43

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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