Document Detail


Defective bronchus-associated lymphoid tissue in long-term surviving rat lung allografts.
MedLine Citation:
PMID:  7551396     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a previous study we found that a local immune response did not develop in the bronchus-associated lymphoid tissue (BALT) of infected rat allografts. We hypothesized that the BALT in rat lung allografts was damaged after allotransplantation. Therefore, we investigated three prerequisites for a normal function of the BALT, i.e., its structure, the uptake of antigens, and the lymphocyte migration to the BALT in three groups of rats (n = 10 each): (1) Brown Norway(BN)-to-Lewis (LEW) allografts; (2) LEW-to-LEW isografts; and (3) normal LEW rats. All rats were immunosuppressed with CsA (injected on days 2 and 3). Six mo after transplantation the structure of the BALT and the uptake of intrabronchially injected carbon particles in the BALT were determined histologically; the migration of intravenously injected, fluoroscein-isothiocyanate labeled lymphocytes to the BALT was determined immunohistochemically. In the allografts the BALT was defective in all three investigated aspects. It was reduced in size and lymphocyte density and was largely replaced by fibrous tissue. Twenty-four h after administration no carbon particles and only a few labeled lymphocytes were found in the BALT. In contrast, in the syngeneically transplanted and nontransplanted lungs the BALT consisted of a large and dense collection of lymphocytes. In these BALTs large numbers of carbon particles and labeled lymphocytes were found. In conclusion, after allogeneic transplantation the BALT in the lung becomes defective in structure and function. The BALT is most likely damaged by rejection, since the BALT is syngeneic lung transplants was perfectly normal.
Authors:
J B Winter; J Prop; M Groen; A H Petersen; T Uyama; B Meedendorp; C R Wildevuur
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  152     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1995-11-01     Completed Date:  1995-11-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1367-73     Citation Subset:  AIM; IM    
Affiliation:
Cardiopulmonary Surgery Research Division, University Hospital Groningen, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bronchi / immunology*,  pathology
Cell Movement
Cyclosporine / therapeutic use
Graft Rejection / immunology*,  pathology
Graft Survival / immunology*
Lung Transplantation / immunology*,  pathology
Lymphocytes / physiology
Lymphoid Tissue / immunology*,  pathology
Male
Rats
Rats, Inbred BN
Rats, Inbred Lew
Specific Pathogen-Free Organisms
Time Factors
Transplantation, Homologous
Transplantation, Isogeneic
Chemical
Reg. No./Substance:
59865-13-3/Cyclosporine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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