Document Detail

Defective B cell development in Snell dwarf (dw/dw) mice can be corrected by thyroxine treatment.
MedLine Citation:
PMID:  8871629     Owner:  NLM     Status:  MEDLINE    
Snell dwarf (dw/dw) mice are deficient in anterior pituitary hormones due to a mutation in the gene encoding the Pit-1 transcription factor. Bone marrow B cell development is also suppressed in the mice, providing circumstantial evidence that one or more anterior pituitary-derived products, or factors induced by them, are required for normal B lymphopoiesis. However, concluding that this is the case is dependent on showing that hormonal treatment of dwarf mice reverses their B cell defects. dw/dw mice were treated with growth hormone (GH), insulin-like growth factor-I (IGF-I), or thyroxine in an attempt to restore bone marrow B lymphopoiesis. GH and IGF-I increased the number of B lineage cells in the bone marrow and spleen but did not restore the frequency of bone marrow pre-B cells to normal. However, bone marrow cellularity in thyroxine-treated dw/dw mice was comparable to that in control animals, and both the frequency and absolute number of B lineage cells had increased to normal or even above normal. Taken together, these data indicate that endocrine factors, especially those regulated by the hypothalamic-pituitary-thyroid axis, are potent B lymphopoietic factors.
E Montecino-Rodriguez; R Clark; A Johnson; L Collins; K Dorshkind
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  157     ISSN:  0022-1767     ISO Abbreviation:  J. Immunol.     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1996-12-17     Completed Date:  1996-12-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3334-40     Citation Subset:  AIM; IM    
Division of Biomedical Sciences, University of California, Riverside 92521, USA.
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MeSH Terms
B-Lymphocytes / drug effects*,  immunology*,  pathology
Bone Marrow / drug effects,  immunology,  pathology
Bone Marrow Transplantation
Dwarfism / drug therapy*,  genetics,  immunology*
Growth Hormone / pharmacology
Hematopoiesis / drug effects
Insulin-Like Growth Factor I / pharmacology
Mice, Inbred BALB C
Mice, Mutant Strains
Mice, SCID
Pituitary Hormones, Anterior / deficiency,  immunology
Thyroxine / pharmacology*
Grant Support
Reg. No./Substance:
0/Pituitary Hormones, Anterior; 67763-96-6/Insulin-Like Growth Factor I; 7488-70-2/Thyroxine; 9002-72-6/Growth Hormone

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