Document Detail

Defect in lectin-induced interleukin 2 production by peripheral blood lymphocytes of patients with invasive urinary bladder carcinoma.
MedLine Citation:
PMID:  3261274     Owner:  NLM     Status:  MEDLINE    
The production of interleukin 2 (IL-2) by phytohaemagglutinin (PHA)-stimulated peripheral blood mononuclear cells (PBMC) from 21 patients with transitional cell carcinoma of the urinary bladder (BTCC) and 16 control blood donors was measured with a solid phase enzyme immunoassay based on the dual antibody immunometric sandwich principle. PBMC from patients with invasive BTCC (grade III-IV) showed a defect in the production of IL-2. The concentration of IL-2 in the supernatants of PBMC cultures from these patients was substantially lower (0.4 +/- 0.1 U/ml) than that observed in the supernatants of PBMC cultures from patients with non-invasive BTCC, grade II (1.5 +/- 0.7 U/ml), and from tumour-free controls (1.4 +/- 0.8 U/ml). These results suggest an immune dysfunction based on quantitatively impaired IL-2 production in patients with invasive BTCC and indicate that exogenous IL-2 could be used as an immunological response modifier for the treatment of these patients.
J Bubeník; J Kieler; V Tromholt; G Hermann; T Jandlová
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Immunology letters     Volume:  18     ISSN:  0165-2478     ISO Abbreviation:  Immunol. Lett.     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-09-15     Completed Date:  1988-09-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7910006     Medline TA:  Immunol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  115-8     Citation Subset:  IM    
Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Prague.
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MeSH Terms
Carcinoma, Transitional Cell / immunology*
Interleukin-2 / biosynthesis*
Lymphocyte Activation
Lymphocytes / immunology*,  metabolism
Middle Aged
Urinary Bladder Neoplasms / immunology*
Reg. No./Substance:
0/Interleukin-2; 0/Phytohemagglutinins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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