Document Detail


Defect in lectin-induced interleukin 2 production by peripheral blood lymphocytes of patients with invasive urinary bladder carcinoma.
MedLine Citation:
PMID:  3261274     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The production of interleukin 2 (IL-2) by phytohaemagglutinin (PHA)-stimulated peripheral blood mononuclear cells (PBMC) from 21 patients with transitional cell carcinoma of the urinary bladder (BTCC) and 16 control blood donors was measured with a solid phase enzyme immunoassay based on the dual antibody immunometric sandwich principle. PBMC from patients with invasive BTCC (grade III-IV) showed a defect in the production of IL-2. The concentration of IL-2 in the supernatants of PBMC cultures from these patients was substantially lower (0.4 +/- 0.1 U/ml) than that observed in the supernatants of PBMC cultures from patients with non-invasive BTCC, grade II (1.5 +/- 0.7 U/ml), and from tumour-free controls (1.4 +/- 0.8 U/ml). These results suggest an immune dysfunction based on quantitatively impaired IL-2 production in patients with invasive BTCC and indicate that exogenous IL-2 could be used as an immunological response modifier for the treatment of these patients.
Authors:
J Bubeník; J Kieler; V Tromholt; G Hermann; T Jandlová
Related Documents :
73344 - Effect of bleomycin on peripheral lymphocytes.
11579714 - Subclinical pulmonary involvement assessed by bronchoalveolar lavage in patients with e...
1837524 - Lymphopenia and decrease in the total number of circulating cd3+ and cd4+ t cells durin...
313034 - Possible nonspecific immunopotentiation by 2,4-dinitrochlorobenzene sensitization in pa...
2484314 - Susceptibility epitope on hla-dr beta chain for rheumatoid arthritis and the effect of ...
20934564 - Impact of prenatal diagnosis and anatomical subtype on outcome in double outlet right v...
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Immunology letters     Volume:  18     ISSN:  0165-2478     ISO Abbreviation:  Immunol. Lett.     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-09-15     Completed Date:  1988-09-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7910006     Medline TA:  Immunol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  115-8     Citation Subset:  IM    
Affiliation:
Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Prague.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Carcinoma, Transitional Cell / immunology*
Humans
Interleukin-2 / biosynthesis*
Lymphocyte Activation
Lymphocytes / immunology*,  metabolism
Middle Aged
Phytohemagglutinins
Urinary Bladder Neoplasms / immunology*
Chemical
Reg. No./Substance:
0/Interleukin-2; 0/Phytohemagglutinins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Interleukin 2 increases protection against experimental rabies.
Next Document:  Detection of human auto-anti-idiotypic antibodies (Ab2). I. Isolation and characterization of Ab2 in...