Document Detail


Default-mode function and task-induced deactivation have overlapping brain substrates in children.
MedLine Citation:
PMID:  18482851     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The regions that comprise the functionally connected resting-state default-mode network (DMN) in adults appear to be the same as those that are characterized by task-induced decreases in blood-oxygen-level-dependent (BOLD) signal. Independent component analysis can be used to produce a picture of the DMN as an individual rests quietly in the scanner. Contrasts across conditions in which cognitive load is parametrically modulated can delineate neural structures that have decreases in activation in response to high-demand task conditions. Examination of the degree to which these networks subsume dissociable brain substrates, and of the degree to which they overlap, provides insight concerning their purpose, function, and the nature of their associations. Few studies have examined the DMN in children, and none have tested whether the neural regions that comprise the DMN during a resting condition are the same regions that show reduced activity when children engage in cognitive tasks. In this paper we describe regions that show both task-related decreases and spontaneous intrinsic activity at rest in children, and we examine the co-localization of these networks. We describe ways in which the DMN in 7-12-year-old children is both similar to and different from the DMN in adults; moreover, we document that task-induced deactivations and default-mode resting-state activity in children share common neural substrates. It appears, therefore, that even before adolescence a core aspect of task-induced deactivation involves reallocating processing resources that are active at rest. We describe how future studies assessing the development of these systems would benefit from examining these constructs as part of one continuous system.
Authors:
Moriah E Thomason; Catherine E Chang; Gary H Glover; John D E Gabrieli; Michael D Greicius; Ian H Gotlib
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-04-01
Journal Detail:
Title:  NeuroImage     Volume:  41     ISSN:  1053-8119     ISO Abbreviation:  Neuroimage     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-16     Completed Date:  2008-08-29     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  9215515     Medline TA:  Neuroimage     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1493-503     Citation Subset:  IM    
Affiliation:
Department of Psychology, Stanford University, Jordan Hall, Building 420, Stanford, CA 94305-2130, USA. moriah@stanford.edu
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MeSH Terms
Descriptor/Qualifier:
Brain / physiology*
Cerebral Cortex / physiology
Child
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Movement / physiology
Nerve Net / anatomy & histology,  physiology*
Neural Pathways / physiology
Neuropsychological Tests
Psychomotor Performance / physiology*
Grant Support
ID/Acronym/Agency:
F31 MH071996-02/MH/NIMH NIH HHS; MH071996/MH/NIMH NIH HHS; MH074849/MH/NIMH NIH HHS; MH61426/MH/NIMH NIH HHS; P41 RR009784-09/RR/NCRR NIH HHS; R01 MH061426-01A1S1/MH/NIMH NIH HHS; R01 MH074849-03/MH/NIMH NIH HHS; RR09784/RR/NCRR NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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