| Defatted bovine colostrum-supplemented diet around weaning improves exocrine pancreatic secretion by means of volume, digestive enzymes, and antibacterial activity. | |
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MedLine Citation:
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PMID: 19136910 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Exocrine pancreatic secretion contributes to limit pathogenic bacteria-associated diarrhea. Bovine colostrum, used in the treatment of diarrhea, reduces symptoms originating from gut pathogenic bacteria overgrowth. We hypothesized that bovine colostrum may stimulate the exocrine pancreatic secretion. METHODS: Eighteen piglets fitted with 2 permanent catheters (for pancreatic juice collection and reintroduction) were allocated to 1 of the following 2 dietary treatments for 5 days: a control diet or a diet supplemented with defatted bovine colostrum. Pancreatic juice was collected daily, and digestive enzyme activities and antibacterial activity were determined. RESULTS: The prandial pancreatic juice outflow, the basal and prandial lipase output, and the basal secretion of the antibacterial activity were, respectively, 60% (P = 0.08), 154% (P = 0.08), 92% (P = 0.06), and 72% (P < 0.05) higher in piglets fed a diet supplemented with defatted bovine colostrum. CONCLUSIONS: With defatted bovine colostrum, the increased antibacterial activity secretion against Escherichia coli may limit pathogenic bacteria overgrowth of the gut and reduce diarrheal episodes. The role of secretin in the increased pancreatic juice flow and lipase secretion was considered. |
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Authors:
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Antoine Huguet; Gérard Savary; Eric Bobillier; Isabelle Le Huërou-Luron |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pancreas Volume: 38 ISSN: 1536-4828 ISO Abbreviation: Pancreas Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-03-25 Completed Date: 2009-05-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8608542 Medline TA: Pancreas Country: United States |
Other Details:
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Languages: eng Pagination: 303-8 Citation Subset: IM |
Affiliation:
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INRA/Agrocampus Ouest, UMR 1079, Rennes, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amylases
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secretion Animals Anti-Bacterial Agents / pharmacology* Cattle Colostrum* Dietary Supplements* Lipase / secretion Pancreas, Exocrine / physiology, secretion* Pancreatic Juice / secretion* Swine Trypsin / secretion Weaning |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; EC 3.1.1.3/Lipase; EC 3.2.1.-/Amylases; EC 3.4.21.4/Trypsin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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